Table 4

Changes from baseline in secondary end points

Secondary end points4-151Change from baseline4-150Difference between strategies
Strategy I (n=107)Strategy II (n=101)Strategy III (n=105)
1 year
 Wellbeing score, mm−17 (−23 to −10)−21 (−28 to −14)−22 (−27 to −16)
 Grip strength, kPa+9 (+6 to +12)+9 (+5 to +13)+14 (+10 to +18) 4-152
 Haemoglobin, mmol/l+0.2 (+0.01 to +0.4)+0.3 (+0.2 to +0.5)+0.3 (+0.2 to +0.4)
 Morning stiffness, min median (10–90 centiles)−30 (−270 to +60)−45 (−178 to +27)−30 (−233 to +23)
 C reactive protein, mg/l median (10–90 centiles)−15 (−66 to +13)−9 (−94 to +14)−12 (−54 to +5)
 Platelet count × 109/l median (10–90 centiles)−33 (−134 to 29)−50 (−166 to +40)−45 (−177 to +17)
2 years
 Wellbeing score, mm−17 (−23 to −11)−24 (−30 to −17)−18 (−24 to −12)
 Grip strength, kPa+12 (+8 to +15)+13 (+8 to +17)+15 (+11 to +20)
 Haemoglobin, mmol/l+0.2 (+0.04 to +0.4)+0.4 (+0.2 to +0.5)+0.4 (+0.2 to +0.5)
 Morning stiffness, min median (10–90 centiles)−45 (−309 to +36)−45 (−150 to +30)−30 (−216 to +45)
 C reactive protein, mg/l median (10–90 centiles)−18 (−74 to +5)−11 (−95 to +6)−5 (−55 to +5)
 Platelet count × 109/l median (10–90 centiles)−42 (−171 to +29)−63 (−206 to +30)−50 (−173 to +19)
  • 4-150 Values are the mean change from baseline and 95% CI for the mean, or the median change and 10–90 centiles, where appropriate.

  • 4-151 Ranges for end points are: wellbeing score 0 to 100 mm; duration of morning stiffness 0 to 720 minutes. Negative values indicate improvement for all end points, except for grip strength and haemoglobin concentration.

  • 4-152 Differences between strategies were not statistically significant, except for grip strength at one year: difference in change in grip strength between strategies I and III was statistically significant : mean difference is 5 and 95% CI of the difference is 0.2 to 10.0, but not between strategies II and III: mean difference is 5 and 95% CI of the difference is −0.2 to 10.0.