Secondary end points^{4-151} | Change from baseline^{4-150} | Difference between strategies | |||
---|---|---|---|---|---|

Strategy I (n=107) | Strategy II (n=101) | Strategy III (n=105) | |||

1 year | |||||

Wellbeing score, mm | −17 (−23 to −10) | −21 (−28 to −14) | −22 (−27 to −16) | ||

Grip strength, kPa | +9 (+6 to +12) | +9 (+5 to +13) | +14 (+10 to +18) |
^{4-152} | |

Haemoglobin, mmol/l | +0.2 (+0.01 to +0.4) | +0.3 (+0.2 to +0.5) | +0.3 (+0.2 to +0.4) | ||

Morning stiffness, min median (10–90 centiles) | −30 (−270 to +60) | −45 (−178 to +27) | −30 (−233 to +23) | ||

C reactive protein, mg/l median (10–90 centiles) | −15 (−66 to +13) | −9 (−94 to +14) | −12 (−54 to +5) | ||

Platelet count × 10^{9}/l median (10–90 centiles) | −33 (−134 to 29) | −50 (−166 to +40) | −45 (−177 to +17) | ||

2 years | |||||

Wellbeing score, mm | −17 (−23 to −11) | −24 (−30 to −17) | −18 (−24 to −12) | ||

Grip strength, kPa | +12 (+8 to +15) | +13 (+8 to +17) | +15 (+11 to +20) | ||

Haemoglobin, mmol/l | +0.2 (+0.04 to +0.4) | +0.4 (+0.2 to +0.5) | +0.4 (+0.2 to +0.5) | ||

Morning stiffness, min median (10–90 centiles) | −45 (−309 to +36) | −45 (−150 to +30) | −30 (−216 to +45) | ||

C reactive protein, mg/l median (10–90 centiles) | −18 (−74 to +5) | −11 (−95 to +6) | −5 (−55 to +5) | ||

Platelet count × 10^{9}/l median (10–90 centiles) | −42 (−171 to +29) | −63 (−206 to +30) | −50 (−173 to +19) |

↵4-150 Values are the mean change from baseline and 95% CI for the mean, or the median change and 10–90 centiles, where appropriate.

↵4-151 Ranges for end points are: wellbeing score 0 to 100 mm; duration of morning stiffness 0 to 720 minutes. Negative values indicate improvement for all end points, except for grip strength and haemoglobin concentration.

↵4-152 Differences between strategies were not statistically significant, except for grip strength at one year: difference in change in grip strength between strategies I and III was statistically significant : mean difference is 5 and 95% CI of the difference is 0.2 to 10.0, but not between strategies II and III: mean difference is 5 and 95% CI of the difference is −0.2 to 10.0.