Table 3

Changes from baseline in primary end points

Primary end points3-151Change from baseline3-150Difference between strategies
Strategy I (n=107)Strategy II (n=101)Strategy III (n=105)
1 year
 Disability score−0.3 (−0.5 to −0.2)−0.4 (−0.5 to −0.2)−0.4 (−0.5 to −0.3)
 Pain score, mm−21 (−27 to −15)−18 (−25 to −12)−24 (−28 to −18)
 Joint score−74 (−99 to −49)−93 (−118 to −67)−95 (−113 to −78)
 ESR, mm/1st h−16 (−20 to −12)−18 (−24 to −12)−20 (−25 to −16)
 Radiological damage 3-152
  Median+6+3+2
  10–90 Centiles0–250–150–14
2 years
 Disability score−0.3 (−0.5 to −0.2)−0.4 (−0.6 to −0.2)−0.3 (−0.4 to −0.2)
 Pain score, mm−22 (−27 to −16)−25 (−31 to −19)−21 (−27 to −16)
 Joint score−89 (−111 to −67)−104 (−128 to −80)−86 (−106 to −66)
 ESR, mm/1st h−19 (−24 to −14)−21 (−27 to −16)−20 (−24 to −15)
 Radiological damage 3-152
  Median+12+9 +8
  10–90 Centiles0–480–280–37
  • 3-150 Values are the mean change from baseline and 95% CI for the mean. For radiological damage values are median change and the 10–90 centiles. Negative values indicate improvement for all end points.

  • 3-151 Ranges for end point measures are as follows: disability score, 0 to 3; pain score, 0 to 100 mm; joint score, 0 to 534; erythrocyte sedimentation rate, 1 to 140 mm/1st h; radiological damage score, 0 to 448.

  • 3-152 Differences between strategies I and II, and between I and III were significant (p<0.05), but not between strategies II and III (Mann-Whitney U test).