Predictors of right ventricular (RV) diastolic function parameters among patients with anticardiolipin antibodies
| Variable | Predictors: effect (p value) | ||
|---|---|---|---|
| Adjusted for age/sex | Multivariate | ||
| RV-E | APS: −4.71 cm (0.026) | APS: −3.93 cm (0.052) | |
| DD: −0.025 cm/year (0.066) | DD: −0.034 cm/year (0.012) | ||
| HTN: 5.04 cm (0.039) | HTN: 7.06 cm (0.0042) | ||
| Anti-β2 GPI: −3.12 cm (0.126) | Age: −0.17 cm/year (0.066) | ||
| Pulmonary HTN: 5.50 cm (0.105) | Male sex: 6.75 cm (0.014) | ||
| RV-A | None | DD: −0.041 cm/year (0.032) | |
| HTN: 6.71 cm (0.0048) | |||
| RV-DT | pAPS: 17.2 ms (0.013) | pAPS: 19.6 ms (0.002) | |
| Pulmonary HTN: 15.6 ms (0.150) | Pulmonary HTN: 20.1 ms (0.038) | ||
| HTN: −18.0 ms (0.016) | |||
| APS: 11.4 ms (0.093) | |||
| RV-IVRT | IgG aCL titre: 0.89 ms (0.060) | IgG aCL titre: 1.10 ms (0.020) | |
| RV-E/A | APS: −0.084 (0.016) | APS: −0.088 (0.010) | |
| Anti-β2 GPI: −0.073 (0.029) | |||
aCL = anticardiolipin antibodies; anti-β2 GPI = antibodies to β2 glycoprotein I; APS = antiphospholipid syndrome; DD = disease duration; HTN = hypertension; pAPS = primary APS. Negative values mean that the respective right ventricular variable is reduced in the presence of the predictor. In the first column, only potentially important predictors with p<0.15, after adjusting for age and sex are shown. In the second column, predictors were selected with a backward elimination process using p>0.10 for variable removal and p<0.05 for entry. These analyses include 27 patients with primary APS, 24 patients with secondary APS, and 30 patients with SLE and aCL without APS. Four patients with APS with lupus anticoagulant, but without aCL are not included.