Table 3

Comparison of cytokine production in biopsy specimens obtained arthroscopically from synovitis in pannus tissue versus distal villous formation of the same joint. Five patients with rheumatoid arthritis with a disease duration of 6–29 years were studied

Patient number Biopsy site IL1α3-150 IL1β3-150 IL63-150 TNFα3-150 Control CD3 CD68
RA-16CPJ3-150 <0.2<0.2<0.2<0.2<0.2NDND
RA-17CPJ6.70.8<0.2<0.2<0.2 6.6 6.7
RA-18Villous6.40.8<0.2<0.21.1 2.0 1.4
RA-18CPJ0.71.2<0.2<0.2<0.2 0.7 0.9
RA-19Villous3.4<0.2<0.2<0.2<0.2 8.215.4
RA-19CPJ0.1<0.20.3<0.2<0.2 5.312.3
RA-20CPJ1.39.2<0.20.9<0.2 1.216.3
  • 3-150 IL1α = interleukin 1α; IL1β = interleukin 1β; IL6 = interleukin 6; TNFα = tumour necrosis factor α; CPJ = cartilage-pannus junction.

  • Cytokine data represent the area occupied by the staining for each cytokine expressed as percentage of the total section area. The results do not indicate any statistically verified differences concerning the expression of the studied cytokines in pannus tissue versus villous formation in individual joints. The size of each tissue section ranged from 2 to 12 mm2.