Table 2

Effect of anti-IL12 treatment on IL1Ra/IL1β and IL10/TNFα ratios

Day of SCW arthritisTreatmentProtein level*
Day 1Control (Igs)0.640.38
Day 1Anti-IL122.270.60
Day 2Control (Igs)0.600.25
Day 2Anti-IL123.550.95
  • Cytokine ratios were calculated after treatment with either rat Igs or anti-IL12. *For protein ratios we used levels of cytokine found in the tisssue chamber model of inflammation (see fig 8).