Effect of anti-IL12 treatment on IL1Ra/IL1β and IL10/TNFα ratios
| Day of SCW arthritis | Treatment | Protein level* | |||
|---|---|---|---|---|---|
| IL1Ra/IL1β | IL10/TNFα | ||||
| Day 1 | Control (Igs) | 0.64 | 0.38 | ||
| Day 1 | Anti-IL12 | 2.27 | 0.60 | ||
| Day 2 | Control (Igs) | 0.60 | 0.25 | ||
| Day 2 | Anti-IL12 | 3.55 | 0.95 | ||
Cytokine ratios were calculated after treatment with either rat Igs or anti-IL12. *For protein ratios we used levels of cytokine found in the tisssue chamber model of inflammation (see fig 8).