Table 3

Histological scores of knee sections after multiple intra-articular injections

Inflammation Proteoglycan depletion
Control+0/+
IL1β (10 ng/knee)++3-150 ++3-150
IL17 (10 ng/knee)++3-150 ++/+++3-150
IL17 (1 ng/knee)++3-150 3-151 +/++3-150 3-151

  • Scoring was blinded for both variables. (Six animals per time point for each cytokine, all right knees were used as controls). Multiple comparisons using Dunnett's test.

  • ↵3-150 p<0.001 versus control.

  • ↵3-151 p<0.05 for IL17 and IL1β at 10 ng/knee.