Table 1

Histological scores of knee sections after a single intra-articular cytokine injection

24 Hours after injection48 Hours after injection
Inflammation1-150Proteoglycan depletion1-150Inflammation1-150Proteoglycan depletion
Control0000
IL1β (10 ng/knee)0/+00/++/++1-151
IL17 (10 ng/knee)00+++1-151
  • Scoring was blinded for both variables. (Five animals per time point for each cytokine, all right knees were used as controls).

  • 1-150 p>0.5 by Kruskal-Wallis test.

  • 1-151 p<0.05 Dunnett's test for multiple comparisons.