Definition of indices
| Index (ref) | Calculation | |
|---|---|---|
| Pooled index (measures A, B, C...)21 | Mean of (change in measure A/SDchange A ; change in measure B/SDchange B; change in measure C/SDchange C ; etc) | |
| Disease activity score (DAS)23 | 0.54(Ritchie index of painful joints) + 0.065(swollen joint count) + 0.33ln (ESR) + 0.072(patient global) | |
| ACR remission24 | 5 out of 6, for a period of 2 months: morning stiffness 15 min, no (joint pain), no joint pain on examination, no joint swelling, ESR <30 mm/1st h (men, <20 mm/1st h), no fatigue | |
| COBRA, “probable” ACR remission9 | 4 out of 5, absence of fatigue assumed (not assessed in trial) | |
| DAS remission25 | DAS ⩽1.6 | |
| ACR improvement (20%)3 | Improvement by at least 20% in tender joint count and swollen joint count plus in at least 3 out of the remaining 5 core set measures: acute phase reactant, physical function, doctor global assessment, patient global assessment, pain | |
| Modified ACR improvement (##%)1-150 | Improvement by at least ##% in tender joint count and swollen joint countplus in at least 3 out of the remaining 5 core set measures | |
| No of core measures improved (##%)26 1-150 | Count of core set measures improved by at least ##% | |
| EULAR response4 | “Good”:improvement in DAS >1.2 and final DAS ⩽2.4 | |
| “Moderate”: not meeting criteria for “good”, but improvement in DAS >0.6and final DAS ⩽3.7 | ||
| “None”: remaining | ||
↵1-150 ##% = thresholds varying from 0 to 70%.