Table 4

Deduced amino acid sequences of the TCR β CDR3 regions of T cell clonotypes that accumulated in multiple joints

BV3nDnBJ
95 95 98 100 103
RA1C A S S LT G RT G E L FJ2S2
C A ST T L P G L V WFJ2S1
C A S SP M KG GT D T QYJ2S3
RA2C A S Embedded Image Y N E Q FJ2S1
C A SS S V A G I G G LY G Y TJ1S2
RA3C AS GT G G G EE T Q YJ2S5
RA4C AI TS G Q G DE Q YJ2S7
C A S S Embedded Image N Y G Y TJ1S2
C A SS L G Q IN Q P Q HJ1S5
RA5C A SR P G Q P YS N Q P Q HJ1S5
BV5S2 nDn BJ
95 96 98 100 103
RA1C A S S LS V F DE Q FJ2S1
RA2C A S SD P G G V Q FY E QYJ2S7
RA3C A S SW S C G R LT D T QYJ2S3
RA4C A S SLL P G L A G K A SN E Q FJ2S1
RA5C A S SF G Q PN E Q FJ2S1
C A S S LRG IK N I QYJ2S4
BV14 nDn BJ
95 95 98 100
RA1C A S SF G LN T E A FJ1S1
C A S SS A R F HN E Q FJ2S1
RA2C AC A G T LY N E Q FJ2S1
RA3C A S SF G G P GT G E L FJ2S2
C A S SF R R GE T QYJ2S5
RA4C A S S LR R QD T QYJ2S3
RA5C A S S S G Q G HY E QYJ2S7

  • Deduced amino acid sequences of the TCR β CDR3 regions of T cell clonotypes that accumulated in multiple joints in each of the five RA patients. Results of the tested three BV families (BV3, BV5S2, BV14) are shown. All the clonotypes shown here were detected at least in two joints. The identical amino acid sequences detected from different patients are shown as follows: LPGL and SGQG, bold; TSG, underlined; GTE, double underlined; and SGT, italic.