Table 2

Effect of human recombinant interleukin1β (hrIL1β) on apoptosis of osteoarthritis (OA) and normal chondrocytes

ControlhrIL1β (ng/ml)
1 ng/ml3 ng/ml10 ng/ml
Patients with OA (4, 9, 10, 11, 12) (n=5)5.0 (2.2)11.5  (3.0)17.9  (4.1)29.5  (6.8)
Controls (15, 16, 17, 18) (n=4)2.9 (1.1)8.1 (1.4)9.2 (1.3)11.4 (2.3)
  • Normal and OA chondrocytes were treated with increasing concentrations of hrIL1β (1, 3, 10 ng/ml) at 37°C for 24 hours. Cells were stained by Annexin-V-fluos to detect apoptotic cells. The ratio of apoptotic cells/total cells was calculated as a percentage, and means (SEM) are shown.

  • See table 1 for references for the patient identification number indicated in brackets.