Table 3

Cytokine gene knockout and transgenic lupus mice

Strain Transgene/Knockout Outcome References
MRL-lpr IFNγ-/-Beneficial 34,35
MRL-lpr IFNγ+/-Beneficial 35
MRL-lpr IFNγR-/-Beneficial 36,37
(NZB X W)F1 IFNγR-/-Beneficial 38
(NZW X B6-γaa)F1 Transgenic IL4Beneficial 52
MRL-lpr IL4-/-Beneficial 34