Table 2

Microscopic features of the synovial membrane in rheumatoid arthritis (RA) with or without joint effusion, spondyloarthropathy (SpA) with or without joint effusion, and osteoarthritis (OA) with or without joint effusion. Mean histological score (standard error of the mean)

RA with joint effusion (n=18)RA without joint effusion (n=12)SpA with joint effusion (n=13)SpA without joint effusion (n=10)OA with joint effusion (n=3)OA without joint effusion (n=9)
Mean lining thickness2.69 (0.30)2-150 1.68 (0.31)2-150 3.48 (0.66)2.02 (0.35)2.47 (0.79)1.40 (0.18)
Max lining thickness2.31 (0.18)1.71 (0.29)1.36 (0.20)1.33 (0.33)1.67 (0.33)1.25 (0.25)
CD68 in lining1.06 (0.24)0.77 (0.26)1.69 (0.24)2-150 0.81 (0.27)2-150 1.33 (0.67)0.89 (0.26)
αVβ3 in lining1.09 (0.31)2-151 1.20 (0.58)2.40 (0.16)2-151 2.25 (0.25)1.33 (0.33)1.00 (0.41)
αVβ5 in lining2.73 (0.14)2.50 (0.50)2.55 (0.16)1.80 (0.49)2.67 (0.33)1.5 (0.87)
Vascularity1.58 (0.14)2-150 2-151 1.04 (0.18)2-150 2.23 (0.29)2-151 1.60 (0.27)2.00 (0.00)0.78 (0.22)
Infiltration1.92 (0.15)2-150 0.59 (0.18)2-150 2.08 (0.25)2-150 0.80 (0.20)2-150 1.50 (0.29)0.22 (0.15)
Neutrophils0.66 (0.17)0.27 (0.20)1.31 (0.35)0.45 (0.24)0.67 (0.33)0.11 (0.11)
Lymphocytes1.92 (0.09)2-150 0.86 (0.23)2-150 1.88 (0.26)2-150 0.95 (0.26)2-150 1.67 (0.33)0.22 (0.15)
Plasma cells0.90 (0.23)2-150 0.09 (0.09)2-150 0.38 (0.15)0.00 (0.00)0.00 (0.00)0.11 (0.11)
CD68 in sublining1.34 (0.28)0.68 (0.27)1.23 (0.20)2-150 0.28 (0.15)2-150 0.67 (0.33)0.33 (0.24)
CD380.44 (0.19)0.17 (0.17)0.56 (0.31)0.14 (0.14)1.07 (0.73)0.33 (0.33)
CD200.94 (0.27)2-151 0.14 (0.10)0.15 (0.15)2-150 2-151 0.22 (0.15)2-150 0.00 (0.00)0.11 (0.11)
CD32.41 (0.16)2-150 2-151 0.64 (0.24)2-150 1.55 (0.27)2-150 2-151 0.58 (0.27)2-150 1.00 (0.00)0.72 (0.28)
CD41.91 (0.19)2-150 2-151 0.32 (0.19)2-150 0.95 (0.24)2-151 0.25 (0.17)1.00 (0.58)0.44 (0.18)
CD81.62 (0.20)2-150 0.45 (0.16)2-150 1.40 (0.28)2-150 0.08 (0.08)2-150 1.00 (0.58)0.44 (0.18)
αVβ5 in sublining2.45 (0.21)2-150 2-151 0.50 (0.50)2-150 0.55 (0.25)2-151 0.00 (0.00)0.33 (0.00)0.00 (0.00)
αVβ3 on endothelium1.64 (0.34)0.4 (0.4)1.20 (0.33)1.00 (0.71)0.00 (0.00)0.00 (0.00)
αVβ5 on endothelium0.46 (0.25)0.0 (0.0)0.09 (0.09)0.00 (0.00)0.00 (0.00)0.00 (0.00)
  • 2-150 p<0.05 for comparison of patients with and without joint effusion within one diagnostic group.

  • 2-151 p<0.05 for comparison of patients with RA with joint effusion and patients with SpA with joint effusion.