Microscopic features of the synovial membrane in rheumatoid arthritis (RA) with or without joint effusion, spondyloarthropathy (SpA) with or without joint effusion, and osteoarthritis (OA) with or without joint effusion. Mean histological score (standard error of the mean)
| RA with joint effusion (n=18) | RA without joint effusion (n=12) | SpA with joint effusion (n=13) | SpA without joint effusion (n=10) | OA with joint effusion (n=3) | OA without joint effusion (n=9) | |
|---|---|---|---|---|---|---|
| Mean lining thickness | 2.69 (0.30)2-150 | 1.68 (0.31)2-150 | 3.48 (0.66) | 2.02 (0.35) | 2.47 (0.79) | 1.40 (0.18) |
| Max lining thickness | 2.31 (0.18) | 1.71 (0.29) | 1.36 (0.20) | 1.33 (0.33) | 1.67 (0.33) | 1.25 (0.25) |
| CD68 in lining | 1.06 (0.24) | 0.77 (0.26) | 1.69 (0.24)2-150 | 0.81 (0.27)2-150 | 1.33 (0.67) | 0.89 (0.26) |
| αVβ3 in lining | 1.09 (0.31)2-151 | 1.20 (0.58) | 2.40 (0.16)2-151 | 2.25 (0.25) | 1.33 (0.33) | 1.00 (0.41) |
| αVβ5 in lining | 2.73 (0.14) | 2.50 (0.50) | 2.55 (0.16) | 1.80 (0.49) | 2.67 (0.33) | 1.5 (0.87) |
| Vascularity | 1.58 (0.14)2-150 2-151 | 1.04 (0.18)2-150 | 2.23 (0.29)2-151 | 1.60 (0.27) | 2.00 (0.00) | 0.78 (0.22) |
| Infiltration | 1.92 (0.15)2-150 | 0.59 (0.18)2-150 | 2.08 (0.25)2-150 | 0.80 (0.20)2-150 | 1.50 (0.29) | 0.22 (0.15) |
| Neutrophils | 0.66 (0.17) | 0.27 (0.20) | 1.31 (0.35) | 0.45 (0.24) | 0.67 (0.33) | 0.11 (0.11) |
| Lymphocytes | 1.92 (0.09)2-150 | 0.86 (0.23)2-150 | 1.88 (0.26)2-150 | 0.95 (0.26)2-150 | 1.67 (0.33) | 0.22 (0.15) |
| Plasma cells | 0.90 (0.23)2-150 | 0.09 (0.09)2-150 | 0.38 (0.15) | 0.00 (0.00) | 0.00 (0.00) | 0.11 (0.11) |
| CD68 in sublining | 1.34 (0.28) | 0.68 (0.27) | 1.23 (0.20)2-150 | 0.28 (0.15)2-150 | 0.67 (0.33) | 0.33 (0.24) |
| CD38 | 0.44 (0.19) | 0.17 (0.17) | 0.56 (0.31) | 0.14 (0.14) | 1.07 (0.73) | 0.33 (0.33) |
| CD20 | 0.94 (0.27)2-151 | 0.14 (0.10) | 0.15 (0.15)2-150 2-151 | 0.22 (0.15)2-150 | 0.00 (0.00) | 0.11 (0.11) |
| CD3 | 2.41 (0.16)2-150 2-151 | 0.64 (0.24)2-150 | 1.55 (0.27)2-150 2-151 | 0.58 (0.27)2-150 | 1.00 (0.00) | 0.72 (0.28) |
| CD4 | 1.91 (0.19)2-150 2-151 | 0.32 (0.19)2-150 | 0.95 (0.24)2-151 | 0.25 (0.17) | 1.00 (0.58) | 0.44 (0.18) |
| CD8 | 1.62 (0.20)2-150 | 0.45 (0.16)2-150 | 1.40 (0.28)2-150 | 0.08 (0.08)2-150 | 1.00 (0.58) | 0.44 (0.18) |
| αVβ5 in sublining | 2.45 (0.21)2-150 2-151 | 0.50 (0.50)2-150 | 0.55 (0.25)2-151 | 0.00 (0.00) | 0.33 (0.00) | 0.00 (0.00) |
| αVβ3 on endothelium | 1.64 (0.34) | 0.4 (0.4) | 1.20 (0.33) | 1.00 (0.71) | 0.00 (0.00) | 0.00 (0.00) |
| αVβ5 on endothelium | 0.46 (0.25) | 0.0 (0.0) | 0.09 (0.09) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |