Propositions to be included in the research agenda based on the opinion of the experts
| Propositions | |
|---|---|
| 1 | There is a need to establish a set of recommendations for uniform and full reporting of clinical trials in knee OA7-150 |
| 2 | There is an urgent need to examine the efficacy and cost utility of surgical techniques |
| 3 | The indications for joint replacement need to be determined |
| 4 | Studies are still required to determine the most efficient effective home exercises for knee OA |
| 5 | The clinical relevance of any structural effect of SYSADOA7-150requires evaluation |
| 6 | What are the long term effects of COX inhibition on joint tissues, primarily, cartilage and bone? |
| 7 | Studies should include quality of life and function, as well as pain, as outcome measures |
| 8 | Clinical predictors of response to pharmacological and non-pharmacological interventions need to be determined |
| 9 | Randomised controlled trials should more fully assess the various non-pharmacological interventions for knee OA |
| 10 | COX-2 specific inhibitors should be compared with paracetamol and with low doses of conventional NSAIDs7-150 in patients with knee OA who have chronic pain |
↵7-150 OA = osteoarthritis; NSAIDs = non-steroidal anti-inflammatory drugs; SYSADOA = symptomatic slow acting drugs for osteoarthritis.