Table 7

Propositions to be included in the research agenda based on the opinion of the experts

1There is a need to establish a set of recommendations for uniform and full reporting of clinical trials in knee OA7-150
2There is an urgent need to examine the efficacy and cost utility of surgical techniques
3The indications for joint replacement need to be determined
4Studies are still required to determine the most efficient effective home exercises for knee OA
5The clinical relevance of any structural effect of SYSADOA7-150requires evaluation
6What are the long term effects of COX inhibition on joint tissues, primarily, cartilage and bone?
7Studies should include quality of life and function, as well as pain, as outcome measures
8Clinical predictors of response to pharmacological and non-pharmacological interventions need to be determined
9Randomised controlled trials should more fully assess the various non-pharmacological interventions for knee OA
10COX-2 specific inhibitors should be compared with paracetamol and with low doses of conventional NSAIDs7-150 in patients with knee OA who have chronic pain
  • 7-150 OA = osteoarthritis; NSAIDs = non-steroidal anti-inflammatory drugs; SYSADOA = symptomatic slow acting drugs for osteoarthritis.