Table 1

Phenotype frequencies of TNFa microsatellite alleles in Japanese SSc (SScJ) and German SSc (SScG) and controls

TNFaSSc (%)ControlsComparison of controls
p Value
whole (J)
54
whole (G)
50
a-Scl-70* (J)
22
a-Scl-70* (G)
20
Japanese
69
German
314
a12 (3.7)01 (4.5)02 (2.9)11 (3.5)NS
a213 (24.1)22 (44)5 (22.7)4 (20)17 (24.6)142 (45.2)0.0218, OR=0.4 (95% CI=0.21, 0.74)
a301 (2)01 (5)09 (2.9)NS
a43 (5.6)4 (8)01 (5)3 (4.3)53 (16.9)NS
a53 (5.6)4 (8)1 (4.5)1 (5)1 (1.4)33 (10.5)NS
a619 (35.2)14 (28)6 (27.3)5 (25)40 (58.0)68 (21.7)<1.0 × 10E-5, OR=4.99 (95% CI=2.79, 8.96)
a73 (5.6)7 (14)2 (9.5)5 (25)2 (2.9)59 (18.8)0.0142, OR=0.13 (95% CI=0.02, 056)
a82 (3.7)1 (2)0002 (0.6)NS
a93 (5.6)2 (4)1 (4.5)1 (5)5 (7.2)15 (4.8)NS
a1014 (25.9)14 (28)4 (18.2)6 (30)13 (18.8)84 (26.8)NS
a1114 (25.9)18 (36)4 (18.2)10 (50)24 (34.8)81 (25.8)NS
a12000004 (1.3)NS
a1323 (42.6)4 (8)14 (63.6)1 (5)14 (20.3)21 (6.7)0.005, OR=3.55 (95% CI=1.60, 7.85)
  • TNFa frequencies in SSc (whole), a-Scl-70*, and controls were compared between the Japanese and German population. No significant differences were found in the distribution of TNF a1-a12 between the patient groups compared with each other and with the controls.

  • p Values of the comparisons of the controls were shown after correction by total number of comparison (13 for TNFa). p Values of the comparisons of TNFa13 frequencies between the patient groups and with the controls were additionally adjusted by the factor 6 (number of the comparisons below).

  • whole SSc(J) v whole SSc(G): p=0.011, OR=8.53 (95% CI=2.46, 32.51)

  • whole SSc(J) v control(J): p=NS, OR=2.91 (95% CI=1.22, 7.00), (without correction p=0.0074)

  • whole SSc(J) v control(G): p<1.0 × 10E-5, OR=10.35 (95% CI=4.88, 22.09)

  • a-Scl-70*(J) v a-Scl-70*(G): p=0.021, OR=33.25 (95% CI=3.39, 800.76)

  • a-Scl-70*(J) v control(J): p=0.028, OR=6.88 (95% CI=1.16, 22.60)

  • a-Scl-70*(J) v control(G): p<1.0 × 10E-5, OR=24.42 (95% CI=8.40, 72.83)