Sillence classification for clinical types of OI
| OI Type | Clinical feature | Inheritance |
| I “Mild” | Normal stature, little or no deformity, blue sclera, hearing loss in 50%, dentinogenesis imperfecta is rare | AD |
| II “Lethal” | Lethal in the perinatal period, minimal calverial mineralisation, beaded ribs, multiple fractures at birth, marked long bone deformities, platyspondyly | AD (new) AR (rare) |
| III “Severe” | Short stature, progressive deforming bones, wheel chair bound by adult life, scleral color varied — bluish gray or white — often lightens with age, dentinogenesis imperfecta and hearing loss common | AD AR (rare) |
| IV “Moderate” | Normal sclera, mild to moderate bony deformity, variable short stature, dentinogenesis imperfecta and hearing loss common | AD |
AD = autosomal dominant, AR = autosomal recessive.