Table 1

Number of engrafted mice, characteristics of RA synovial membrane grafts, and therapeutic protocols. Histological classification according to Stiehl (see in Methods20; BA: basic activity, AA: actual activity, type III: mixed type with characteristics from type I and type II)

GraftHistological diagnosis of the engrafted RA-SMNumber of engrafted miceDuration of experiment (weeks)Treatment
RA-SMRA type III,58Rat-α-murine TNFα moAb, 120 μg ip
1BA II,AA 0-I58Isotype control, 120 μg ip
58None
RA-SMRA type III,512Rat-α-murine TNFα moAb, 300 μg ip
2BA II, AA II512Isotype control, 300 μg ip
512None
Sham operationNone58None
512None
NoneNone58None
512None