Clinical and laboratory measures before treatment (baseline) and at three monthly intervals after treatment with either Sm-153 PHYP + TH or TH alone
| Clinical or laboratory measure (mean (SD)) | Baseline | 3 months | 6 months | 9 months | 12 months | ||
|---|---|---|---|---|---|---|---|
| Knee flexion range (°) | Sm-153 PHYP +TH | 112 (16) | 126 (17) | 128 (17) | 131 (16) | 133 (16) | |
| n=31 | n=29 | n=18 | n=13 | n=10 | |||
| TH | 113 (15) | 121 (25) | 129 (15) | 126 (15) | 135 (15) | ||
| n=29 | n=28 | n=19 | n=10 | n=7 | |||
| Knee circumference (cm) | Sm-153 PHYP +TH | 41 (4) | 41 (4) | 40 (4) | 39 (3) | 41 (4) | |
| n=31 | n=29 | n=18 | n=13 | n=10 | |||
| TH | 41 (4) | 39 (4) | 38 (3) | 39 (4) | 38 (2) | ||
| n=29 | n=22 | n=19 | n=10 | n=7 | |||
| Swollen joint count (scored out of 34) | Sm-153 PHYP +TH | 4 (3) | 3 (3) | 3 (3) | 4 (5) | 3 (3) | |
| n=31 | n=29 | n=18 | n=13 | n=10 | |||
| TH | 4 (4) | 0 (0.5) | 4 (4) | 3 (2) | 3 (3) | ||
| n=28 | n=28 | n=19 | n=10 | n=7 | |||
| Ritchie score (pain score out of 34) | Sm-153 PHYP +TH | 6 (7) | 5 (7) | 4 (4) | 6 (10) | 4 (3) | |
| n=31 | n=29 | n=18 | n=13 | n=10 | |||
| TH | 6 (6) | 3 (4) | 5 (7) | 2 (2) | 2 (2) | ||
| n=29 | n=28 | n=19 | n=10 | n=7 | |||
| Haemoglobin (g/dl) | Sm-153 PHYP +TH | 13.0 (14) | 13.2 (15) | 13.1 (14) | 12.9 (14) | 13.9 (15) | |
| n=27 | n=25 | n=15 | n=10 | n=5 | |||
| TH | 12.4 (15) | 12.3 (16) | 12.1 (5) | 12.7 (12) | 12.2 (5) | ||
| n=22 | n=25 | n=14 | n=6 | n=7 | |||
| Platelets (×109/mm3) | Sm-153 PHYP +TH | 293 (73) | 315 (90) | 309 (85) | 282 (74) | 261 (75) | |
| n=27 | n=25 | n=15 | n=10 | n=5 | |||
| TH | 339 (96) | 361 (148) | 390 (195) | 350 (184) | 347 (74) | ||
| n=22 | n=25 | n=14 | n=6 | n=7 | |||
| ESR (mm 1st h) | Sm-153 PHYP +TH | 32 (27) | 37 (32) | 32 (28) | 33 (27) | 18 (18) | |
| n=27 | n=25 | n=14 | n=10 | n=7 | |||
| TH | 47 (34) | 44 (32) | 52 (36) | 38 (40) | 56 (32) | ||
| n=22 | n=25 | n=14 | n=5 | n=7 | |||
n = the number of patients for whom data were available at that time.