Variable | Patients with sicca symptoms (n=56) | Patients who developed SS (n=31) | |||||
---|---|---|---|---|---|---|---|
Baseline | Follow up | Baseline | Follow up | ||||
Number of patients positive for | |||||||
Waaler-Rose | 9/55 (16%) | 4/31 (13%) | |||||
fs-RF | 11/56 (20%) | 10/31 (32%) | |||||
ANA-ab | 2/56 (3%) | 9/56 (16%) | 8/31 (26%)* | 18/31 (58%) | |||
DNA-ab | 0/48 | 7/56 (12%) | 2/29 (7%) | 6/31 (19%) | |||
ENA-ab | |||||||
RNP | 2 (4%) | 2/30 (7%) | |||||
Sm | 1 (2%) | 2/30 (7%) | |||||
SS-A-ab | 3/56 (5%) | 12/30 (40%) | |||||
SS-B-ab | 2/56 (4%) | 10/30 (33%) | |||||
Scl70 | 0/11 | 1/8 (13%) | |||||
Salivary gland antibodies | 8/56 (14%) | 1/31 (3%) | |||||
S-IgA (g/l) | 2.18 (0.93) | 2.36 (1.09) | 2.46 (1.19) | 2.93 (2.10) | |||
S-IgG (g/l) | 12.9 (4.4) | 12.7 (3.8) | 16.6 (7.1)** | 15.2 (4.8) | |||
S-IgM (g/l) | 1.60 (1.43) | 1.72 (2.02) | 1.41 (0.80) | 1.45 (0.76) | |||
S-γ globulin (g/l) | 11.8 (3.6) (n=50) | 15.1 (7.3)**(n=28) | |||||
S-β2m (mg/l) | 1.63 (0.50) | 1.78 (0.73) | 2.15 (0.56)*** | 2.43 (1.46) |
The baseline concentrations were compared with Student’s t test and the occurrence of autoantibodies at baseline was compared with χ2 test. Significances: *p⩽0.01, **p⩽0.005,***p⩽0.0005.
RF = Rheumatoid factor; ANA-ab = antinuclear antibodies; DNA-ab = antibodies to double-stranded DNA; ENA-ab = antibodies to extractable nuclear antigen; S-β2m = serum β2-microglobulin. Data shown as mean (SD) and percentages.