Allele frequency (%) of GM/KM allotypes in SSc patients according to the presence or absence of SSc related ANAs
| Ig allotypes | Anti-topo I antibody | Anti-U1snRNP antibody | ACA | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Positive (n=37) | Negative (n=68) | p Value | OR (95% CI) | Positive (n=35) | Negative (n=70) | p Value | OR (95% CI) | Positive (n=23) | Negative (n=82) | p Value | OR (95% CI) | ||||
| G1M | f | 22 | 21 | ns | 1.1 (0 to 2.8) | 26 | 19 | ns | 1.5 (0.38 to 6.0) | 4 | 26 | 0.04 | 0.13 (0.02 to 0.79) | ||
| z | 100 | 99 | ns | — | 97 | 100 | ns | — | 100 | 99 | ns | — | |||
| G2M | n+ | 24 | 21 | ns | 1.2 (0.14 to 10.8) | 29 | 19 | ns | 1.8 (0.53 to 5.8) | 4 | 27 | 0.02 | 0. 12 (0.02 to 0.73) | ||
| n− | 100 | 99 | ns | — | 97 | 100 | ns | — | 100 | 99 | ns | — | |||
| G3M* | b | 24 | 24 | ns | 1.0 (0.86 to 1.1) | 30 | 21 | ns | 1.6 (0.43 to 6.1) | 9 | 28 | ns | 0.24 (0.04 to 1.3) | ||
| g | 94 | 92 | ns | 1.4 (0 to 105) | 90 | 94 | ns | 0.57 (0.01 to 27.1) | 100 | 91 | ns | — | |||
| KM | (1,2) | 57 | 54 | ns | 1.1 (0 to 105) | 51 | 57 | ns | 0.79 (0.22 to 2.9) | 52 | 56 | ns | 0.85 (0.03 to 22.2) | ||
| 3 | 86 | 94 | ns | 0.4 (0.06 to 2.5) | 91 | 91 | ns | 1.0 (1.0 to 1.0) | 96 | 90 | ns | 2.4 (0.03 to 170) | |||
ns = Not significant (p>0.05). *Eight SSc patients in whom G3M was untypable were excluded.