Data for before and after treatment
| Overproducers Allopurinol (n=23) (Group 1) | Underexcretors Allopurinol (n=26) (Group 2) | Underexcretors Benzbromarone (n=36) (Group 3) | p Value (for intergroup comparisons) | |
|---|---|---|---|---|
| Age (y) | 51.4 (8.2) | 53.8 (6.4) | 53.1 (19.8) | NS |
| Onset (y) | 9.7 (6.3) | 7.9 (5.7) | 8.3 (7.5) | NS |
| Tophi (%) | 43.4 | 46.1 | 31.4 | NS |
| iPur (mg/dl) | 8.60 (0.92) | 9.10 (1.36) | 8.58 (1.36) | NS |
| fPur (mg/dl) | 5.85 (0.87)*** | 5.76 (1.33)*** | 3.54 (1.21)*** | 1 and 2 v 3 <0.001 |
| Red Pur (%) | 31.69 (9.31) | 36.26 (13.08) | 58.27 (14.48) | 1 and 2v 3 <0.001 |
| iCcr (ml/min) | 116 (22) | 108 (21) | 87 (22) | 1 and 2 v 3 <0.05 |
| fCcr (ml/min) | 119 (23) | 110 (22) | 104 (22)** | NS |
| iCur (ml/min) | 6.71 (0.70) | 4.52 (1.05) | 3.89 (1.15) | 2v 3 NS |
| fCur (ml/min) | 6.60 (1.30) | 4.98 (1.56) | 18.43 (9.31)*** | 2 v 3 <0.001 |
| i24 h Uur (mg) | 831 (113) | 584 (132) | 474 (132) | 1 v 2 and 3 <0.01 |
| f24 h Uur (mg) | 559 (145)** | 404 (125)** | 819 (190)*** | 1 and 2 v 3 <0.001 |
iPur = initial plasmatic urate; fPur = final plasmatic urate; red Pur (%) = percentage of reduction from initial plasmatic urate (red Pur = (iPur−fPur)/iPur×100). iCcr = initial clearance of creatinin; fCcr = final clearance of creatinin; iCur = initial clearance of urate; fCur = final clearance of urate; i24 h Uur = initial 24 h urinary excretion of urate; f24 h Uur = final 24 h urinary excretion of urate. **Final v initial values p<0.01.***Final v initial values p<0.001. Data shown as mean (SD).