Reflected and escaping fractions of large macromolecules across synovium, calculated from intra-articular half lives using equation 7a/b
| Source | Test macromolecule | t½Intra-articular half life (h) | R Reflected fraction | E Escaping fraction | |||||
|---|---|---|---|---|---|---|---|---|---|
| Test macromolecule | Flow marker (albumin) | ||||||||
| Page-Thomas et al 18 | Large cartilage proteoglycan | 12.5 (0.7) | 3.9 (0.8) h | 0.69 | 0.31 | ||||
| Coleman et al 5 | Native synovial hyaluronan | 26.3 h | 1.23 h | 0.95 | 0.05 | ||||
Data shown as mean (SEM).