Table 1

Course(1-150) of RA during pregnancy in relation to incompatibility of DRB1, DQA1, and DQB1 between mother and child

IncompatibilityFavourable (n=21–23)Unfavourable (n=5–6)OR (95% CI)
DRB1+1950.95 (0.09, 10.5)
41
DQA1+1632.67 (0.42, 17.05)
63
DQB1+1942.38 (0.17, 33.00)
21
  • 1-150 Course: disease activity of RA during pregnancy. Favourable: remission or amelioration of disease during pregnancy according to the criteria described in the methods. Unfavourable: active disease during pregnancy according to the criteria described in the methods. In 12 pregnancies the course of RA did not change and among these were 11 DRB1, 10 DQA, and 7 DQB incompatibilities; they were not included in the calculations. Incompatibility: when a child has an allele that is different from both maternal alleles. In some cases it was not possible to differentiate between incompatibility and compatibility according to the HLA data and they were left out, so the number of pregnancies vary for the different class II subtypes.