Table 2

Comparison of V5S1 genotypes between DR4+ and DR4− RA patients and controls

HLA-DR4 statusV5S12-15001/2-15001V5S12-15001/2-15002V5S12-15002/2-15002
UK RA 1 DR4+n=4931  (0.63)14  (0.29)4  (0.08)χ2=7.187
UK RA 1 DR4−n=268 (0.31)14 (0.54)4 (0.15) 2-150p=0.0275 (2df)
UK RA 2 DR4+n=4329 (0.67)11 (0.26)3 (0.07)χ2=3.9
UK RA 2 DR4−n=2310 (0.43)9 (0.4)4 (0.17)p=0.14 (2df)
UK RA 3 DR4+n=5228 (0.54)15 (0.29)9 (0.17)
UK RA 3 DR4−n=3520 (0.57)12 (0.34)3 (0.09)
Total UK RA DR4+n=14488 (0.61)40 (0.28)16 (0.11)χ2=7.78
Total UK RA DR4−n=8438 (0.45)35 (0.42)11 (0.13)p=0.02 (2df)
UK Control DR4+n=3115 (0.48)14 (0.45)2 (0.07)
UK Control DR4−n=7835 (0.45)32 (0.41)11 (0.14)
Swiss RA DR4+n=6737 (0.55)19 (0.28)11 (0.16)
Swiss RA DR4−n=6534 (0.52)26 (0.4)5 (0.08)
Swiss Control DR4+n=198 (0.42)7 (0.37)4 (0.21)
Swiss Control DR4−n=6947 (0.68)14 (0.2)8 (0.12)
Total RA DR4+n=211125 (0.59)59 (0.28)27 (0.13)χ2=6.63
Total RA DR4−n=14972 (0.48)61 (0.41)16 (0.11)p=0.036 (2df)
Total Control DR4+n=5023 (0.46)21 (0.42)6 (0.12)
Total Control DR4−n=14782 (0.56)46 (0.31)19 (0.13)
  • 2-150 p Value corrected for multiple comparisons=0.0275 × 5=0.14.