Table 2

Clinical features of the families who showed genetic anticipation (n=33)

ParentChildParentChildParent
Sex Symptom (AO) CAI Sex Symptom (AO) CAI Sex Symptom (AO) CAI Sex Symptom (AO) CAI Sex Symptom (AO) CAI
1 MOA (38)7MOA (29)46 MOA (31)7MOA (11)611 FOA (20)4
EYE (38)EN (29)GU (33)MS (11)GU (20)
MS (38)MS (29)OF (33)EN (11)OF (30)
OF (29)EN (33)EYE (13)EN (30)
GU (29)EYE (33)EYE (45)
2 MOA (16)8FMS (11)67 FOA (22)5MOA (17)212 FOA (46)5
MS (16)OA (12)GU (22)OF (17)OF (47)
OF (20)GU (12)EN (22)EN (15)GU (47)
GU (27)EN (12)MS (22)MS (47)
EYE (27)EYE (12)EYE (34)EYE (47)
EN (30)
3 FOA (30)2FOA (13)58 MOA (38)6MOA (21)1013 MOA (38)8
GU (29)GU (19)GU (38)OF (21)GU (38)
MS (20)EN (39)EN (21)OF (38)
EN (20)OF (39)MS (21)EYE (38)
EYE (21)MS (39)GU (23)PA (44)
EYE (25)
4 MOA (30)5MOA (19)49MOA (49)8MOF (39)514 FOA (30)4
GU (30)GU (19)GU (49)MS (39)GU (30)
EYE (38)OF (19)EN (49)EYE (39)MS (40)
MS (41)MS (20)EYE (52)GU (40)EN (48)
OA (41)
5 MOA (32)8MNEU (22)1110 FOA (18)3FOA (17)315 FOA (46)3
GU (32)GU (23)GU (34)GU (18)GU (46)
EYE (32)EN (25)OF (34)OF (18)EN (56)
MS (33)OA (25)MS (34)MS (18)
TB (25)
ChildChildChild
Sex Symptom (AO) CAI Sex Symptom (AO) CAI Sex Symptom (AO) CAI
MOA (16)4FOA (14)2FOA (15)2
OF (20)GU (14)GU (15)
EN (20)
GU (24)
MS (25)
MOA (25)2
GU (25)
MOA (22)3
OF (22)
EYE (22)
MOA (19)3
GU (19)
OF (19)
MS (28)
FOA (24)7FOA (19)7
GU (24)GU (21)
EYE (25)OF (21)
EN (25)EN (21)
EYE (21)
  • M= male, F= female, CAI= clinical activity index, AO=age of onset, OA= oral aphtae, EN= erythema nodosum, MS= musculoskeletal involvement, OF= ostiofolliculitis, U= genital ulcer, EYE= uveitis, TB= thrombophlebitis, NEU= neurological involvment.