Table 3

Disease activity parameters of 51 patients with RA before discontinuation of second line drug treatment, at the moment of a recurrence of RA immediately before treatment resumption, and three months after resumption of the same second line drug therapy

Parameter Before treatment discontinuation During flare, before treatment resumption Three months after treatment resumption p Value* p Value**
Pain at rest0.2  (0.5)1.4  (1.0)0.6  (0.8)0.020.00
Pain on active movement0.7  (0.9)2.0  (0.9)1.3  (1.0)0.000.00
Fatigue score0.1  (0.5)1.5  (1.1)1.0  (1.1)0.000.01
Morning stiffness  (min)9  (18)113  (133)51  (97)0.000.00
Grip strength  (kPa)
 Right hand58  (20)40  (20)47  (23)0.000.00
 Left hand57  (20)40  (19)43  (22)0.000.14
HAQ score0.5  (0.6)1.0  (0.8)0.7  (0.8)0.000.00
Ritchie articular index2.7  (2.8)10.5  (5.8)7.1  (6.2)0.000.00
Number of swollen joints0.8  (1.0)3.8  (2.3)2.9  (2.2)0.000.01
ESR  (mm/1st h)15  (11)28  (18)24  (19)0.000.01
CRP  (mg/l)7  (7)15  (13)13  (14)0.000.07
  • Data shown as mean  (SD). * p Value of Wilcoxon signed rank test for comparison between parameters measured before treatment discontinuation and three months after treatment resumption. p Value of Wilcoxon signed rank test for comparison between parameters measured at the time of a flare and three months after treatment resumption.