Effect of GM-CSF on incidence and average clinical score of CIA1-150
| GM-CSF | Days | Kill† | Incidence (n) | Average clinical score‡ | ||||||
| − | + | − | + | |||||||
| Experiment 1 | 21–25 | 45 | 2/10 | 7/10 | 0.1 (0.1) | 1.3 (0.5)§ | ||||
| Experiment 2 | 20–23 | 43 | 9/10 | 8/8 | 1.2 (0.3) | 3.4 (0.7)§ | ||||
| Experiment 3 | 21–24 | 58 | 7/10 | 10/10 | 1.4 (0.5) | 3.4 (0.6)§ | ||||
↵1-150 DBA/1 mice, immunised with chick CII, were given daily ip injections at different times (see Days) with either 15 μg GM-CSF (+) or vehicle (−) and the arthritis assessed by clinical score every two to three days. † Day of death. ‡ The average clinical score of each mouse was determined for the period immediately following GM-CSF, or vehicle treatment, to death. Values show the mean (SEM) of these values for the groups of mice. § p < 0.05 compared with vehicle control.