Clinical features of Whipple’s disease
| Symptoms | Signs | |
|---|---|---|
| Gastrointestinal | Weight loss2-150 | Occult blood loss2-150 |
| Diarrhoea2-150 | Abdominal distension2-150 | |
| Anorexia2-150 | Cachexia | |
| Abdominal pain2-150 | Ascites | |
| Melaena | Hepatomegaly | |
| Splenomegaly | ||
| Glossitis | ||
| Musculoskeletal | Arthralgia2-150 | Arthritis2-150 |
| Myalgia | Sacroiliitis | |
| Respiratory | Chronic cough | Pleural rub |
| Pleuritic pain | ||
| Cardiovascular | Pericardial pain | Congestive cardiac failure |
| Heart murmurs | ||
| Hypotension | ||
| Neurological/psychiatric | Insomnia | Dementia |
| Headache | Peripheral neuropathy | |
| Depression | Ataxia | |
| Fits | Ophthalmoplegia | |
| Visual disturbance | Nystagmus | |
| Memory loss | Myoclonus | |
| Personality change | Hypothalamic dysfunction | |
| Other | Fever2-150 | Peripheral and abdominal lymphadenopathy |
| Fatigue2-150 | Anaemia | |
| Hyperpigmentation | ||
| Night sweats | Uveitis |
↵2-150 Common (more than 50% of cases in most series).