%PDF-1.3 % 8 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 9 0 R /F2 10 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 595 841] /Filter /FlateDecode /Length 579 /Matrix [1 0 0 1 0 0] >> stream xTɊAWXfƚ C F<}0VU2EmAc}b))QnxtiZz2MC%O_Cz{T5U.#I"sJ5mw+!喲fW#9[f9eq'۹z;t6C/&|e/aY W떈v[Aߺ1467h rȲ nR7óx+x#=oGu V%*Q`ZhjNCgm@JE k~he=H퐋z"i9Qo[|%+Y;R(cHJiTThR8YcδYhr9Z+^4ҲV.l \ŷ\ʔrR>ƒ]wq1_,o f/槸Y' Y)/Q%l,UaV ^A=$e {7h֓3>}U=ĩF3L)I@7/{ ̒hn5s <&VC !{İ endstream endobj 7 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 9 0 R /F2 10 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 595 841] /Filter /FlateDecode /Length 579 /Matrix [1 0 0 1 0 0] >> stream xTɊAWXfƚ C F<}0VU2EmAc}b))QnxtiZz2MC%O_Cz{T5U.#I"sJ5mw+!喲fW#9[f9eq'۹z;t6C/&|e/aY W떈v[Aߺ1467h rȲ nR7óx+x#=oGu V%*Q`ZhjNCgm@JE k~he=H퐋z"i9Qo[|%+Y;R(cHJiTThR8YcδYhr9Z+^4ҲV.l \ŷ\ʔrR>ƒ]wq1_,o f/槸Y' Y)/Q%l,UaV ^A=$e {7h֓3>}U=ĩF3L)I@7/{ ̒hn5s <&VC !{İ endstream endobj 6 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 9 0 R /F2 10 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 595 841] /Filter /FlateDecode /Length 579 /Matrix [1 0 0 1 0 0] >> stream xTɊAWXfƚ C F<}0VU2EmAc}b))QnxtiZz2MC%O_Cz{T5U.#I"sJ5mw+!喲fW#9[f9eq'۹z;t6C/&|e/aY W떈v[Aߺ1467h rȲ nR7óx+x#=oGu V%*Q`ZhjNCgm@JE k~he=H퐋z"i9Qo[|%+Y;R(cHJiTThR8YcδYhr9Z+^4ҲV.l \ŷ\ʔrR>ƒ]wq1_,o f/槸Y' Y)/Q%l,UaV ^A=$e {7h֓3>}U=ĩF3L)I@7/{ ̒hn5s <&VC !{İ endstream endobj 5 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 9 0 R /F2 10 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 595 841] /Filter /FlateDecode /Length 579 /Matrix [1 0 0 1 0 0] >> stream xTɊAWXfƚ C F<}0VU2EmAc}b))QnxtiZz2MC%O_Cz{T5U.#I"sJ5mw+!喲fW#9[f9eq'۹z;t6C/&|e/aY W떈v[Aߺ1467h rȲ nR7óx+x#=oGu V%*Q`ZhjNCgm@JE k~he=H퐋z"i9Qo[|%+Y;R(cHJiTThR8YcδYhr9Z+^4ҲV.l \ŷ\ʔrR>ƒ]wq1_,o f/槸Y' Y)/Q%l,UaV ^A=$e {7h֓3>}U=ĩF3L)I@7/{ ̒hn5s <&VC !{İ endstream endobj 4 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 9 0 R /F2 10 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 595 841] /Filter /FlateDecode /Length 579 /Matrix [1 0 0 1 0 0] >> stream xTɊAWXfƚ C F<}0VU2EmAc}b))QnxtiZz2MC%O_Cz{T5U.#I"sJ5mw+!喲fW#9[f9eq'۹z;t6C/&|e/aY W떈v[Aߺ1467h rȲ nR7óx+x#=oGu V%*Q`ZhjNCgm@JE k~he=H퐋z"i9Qo[|%+Y;R(cHJiTThR8YcδYhr9Z+^4ҲV.l \ŷ\ʔrR>ƒ]wq1_,o f/槸Y' Y)/Q%l,UaV ^A=$e {7h֓3>}U=ĩF3L)I@7/{ ̒hn5s <&VC !{İ endstream endobj 3 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 9 0 R /F2 10 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 595 841] /Filter /FlateDecode /Length 579 /Matrix [1 0 0 1 0 0] >> stream xTɊAWXfƚ C F<}0VU2EmAc}b))QnxtiZz2MC%O_Cz{T5U.#I"sJ5mw+!喲fW#9[f9eq'۹z;t6C/&|e/aY W떈v[Aߺ1467h rȲ nR7óx+x#=oGu V%*Q`ZhjNCgm@JE k~he=H퐋z"i9Qo[|%+Y;R(cHJiTThR8YcδYhr9Z+^4ҲV.l \ŷ\ʔrR>ƒ]wq1_,o f/槸Y' Y)/Q%l,UaV ^A=$e {7h֓3>}U=ĩF3L)I@7/{ ̒hn5s <&VC !{İ endstream endobj 2 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 9 0 R /F2 10 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 595 841] /Filter /FlateDecode /Length 579 /Matrix [1 0 0 1 0 0] >> stream xTɊAWXfƚ C F<}0VU2EmAc}b))QnxtiZz2MC%O_Cz{T5U.#I"sJ5mw+!喲fW#9[f9eq'۹z;t6C/&|e/aY W떈v[Aߺ1467h rȲ nR7óx+x#=oGu V%*Q`ZhjNCgm@JE k~he=H퐋z"i9Qo[|%+Y;R(cHJiTThR8YcδYhr9Z+^4ҲV.l \ŷ\ʔrR>ƒ]wq1_,o f/槸Y' Y)/Q%l,UaV ^A=$e {7h֓3>}U=ĩF3L)I@7/{ ̒hn5s <&VC !{İ endstream endobj 1 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 9 0 R /F2 10 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 595 841] /Filter /FlateDecode /Length 579 /Matrix [1 0 0 1 0 0] >> stream xTɊAWXfƚ C F<}0VU2EmAc}b))QnxtiZz2MC%O_Cz{T5U.#I"sJ5mw+!喲fW#9[f9eq'۹z;t6C/&|e/aY W떈v[Aߺ1467h rȲ nR7óx+x#=oGu V%*Q`ZhjNCgm@JE k~he=H퐋z"i9Qo[|%+Y;R(cHJiTThR8YcδYhr9Z+^4ҲV.l \ŷ\ʔrR>ƒ]wq1_,o f/槸Y' Y)/Q%l,UaV ^A=$e {7h֓3>}U=ĩF3L)I@7/{ ̒hn5s <&VC !{İ endstream endobj 9 0 obj << /Encoding /WinAnsiEncoding /Subtype /Type1 /Type /Font /BaseFont /Times-Italic >> endobj 10 0 obj << /Encoding /WinAnsiEncoding /Subtype /Type1 /Type /Font /BaseFont /Times-Roman >> endobj 11 0 obj << /Filter /FlateDecode /Length 10 >> stream x+ | endstream endobj 12 0 obj << /Filter /FlateDecode /Length 43 >> stream xS**T0T0 B0glhafi ] endstream endobj 13 0 obj << /Filter /FlateDecode /Length 10 >> stream x+ | endstream endobj 14 0 obj << /Filter /FlateDecode /Length 43 >> stream xS**T0T0 B0glhafi x\ endstream endobj 15 0 obj << /Filter /FlateDecode /Length 10 >> stream x+ | endstream endobj 16 0 obj << /Filter /FlateDecode /Length 43 >> stream xS**T0T0 B0glhafi o[ endstream endobj 17 0 obj << /Filter /FlateDecode /Length 10 >> stream x+ | endstream endobj 18 0 obj << /Filter /FlateDecode /Length 43 >> stream xS**T0T0 B0glhafi fZ endstream endobj 19 0 obj << /Filter /FlateDecode /Length 10 >> stream x+ | endstream endobj 20 0 obj << /Filter /FlateDecode /Length 43 >> stream xS**T0T0 B0glhafi ]Y endstream endobj 21 0 obj << /Filter /FlateDecode /Length 10 >> stream x+ | endstream endobj 22 0 obj << /Filter /FlateDecode /Length 43 >> stream xS**T0T0 B0glhafi TX endstream endobj 23 0 obj << /Filter /FlateDecode /Length 10 >> stream x+ | endstream endobj 24 0 obj << /Filter /FlateDecode /Length 43 >> stream xS**T0T0 B0glhafi KW endstream endobj 25 0 obj << /Filter /FlateDecode /Length 10 >> stream x+ | endstream endobj 26 0 obj << /Filter /FlateDecode /Length 43 >> stream xS**T0T0 B0glhafi BV endstream endobj 27 0 obj << /Type /Catalog /Pages 28 0 R /Outlines 29 0 R >> endobj 28 0 obj << /Kids [30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R] /Type /Pages /Count 8 >> endobj 30 0 obj << /Resources << /Font 38 0 R /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject << /Xi0 1 0 R >> /ExtGState 39 0 R >> /Rotate 0 /Contents [25 0 R 40 0 R 26 0 R] /Parent 28 0 R /Type /Page /MediaBox [0 0 595.2 841.92] /CropBox [0 0 595.2 841.92] >> endobj 29 0 obj << /Last 41 0 R /First 41 0 R /Count 4 >> endobj 41 0 obj << /Parent 29 0 R /Title (Supplementary material) /Last 42 0 R /First 43 0 R /Dest [30 0 R /XYZ 70.0 757.0 0] /Count 3 >> endobj 43 0 obj << /Parent 41 0 R /Title (Progressive interstitial lung disease measured by forced vital capacity changes in combination with diffusion capacity of the lungs for carbon monoxide changes over 12-month periods) /Next 44 0 R /Dest [30 0 R /XYZ 70.0 727.0 0] >> endobj 44 0 obj << /Parent 41 0 R /Title (Materials and methods) /Next 42 0 R /Prev 43 0 R /Dest [30 0 R /XYZ 70.0 550.0 0] >> endobj 42 0 obj << /Parent 41 0 R /Title (Results) /Prev 44 0 R /Dest [30 0 R /XYZ 70.0 322.0 0] >> endobj 40 0 obj << /Filter /FlateDecode /Length 6586 >> stream x\]Fvm/l`aػ16yІhhVU ˲(-.}nMO0=H9>/1EֽQmD'x&duVvO__k)Q/Nh¯mսQ9h+UTl1ݽ9nV[e\5m+k{]ͥhzzw6ovvvF֛ŕr+|^7aZ빐NQWr.z|6\ S|2[K^]_-\~'l#M=f)h֛W4#'ZrEc[{x3\(uXH*e/|LO"LVB]W`HAzh 8+dL{e9m3F`t}R&YYFIGqRY;T#UgLS'sSvbbʵH0ج\ΏH\BD+ӫSܔI]#m]IuvLPUGidW1Y#BZ&VVv;y-59KZƘkRMO7iN@H[]6a"CgsZ]2^b6NկuR^_вKRxoѐ&9LjTRAaSv2(đdc̑ hf|7iu0a2+z3;+J~h J Id˃VeߌԦ !NjHa>EUk!Sؠ^ї&K*Ug p#`Kqָp,VO(r*b!c*Qi%a%^vBz A)+`C$7cbի9 ,n6oI|FWov!䥭W'08 áve5[}KV?a|5ҝOLAԝʦ1WB)m}0'( gwҊڶPMg_m7ZJY\q"P(Q@^ 0jyF[i"awYi(gas)uPka% 8IpS 5D:z#ί² z=p1[$ְk c# tE"~)B[2S