RT Journal Article
SR Electronic
T1 Power Doppler signal at the enthesis and bone erosions are the most discriminative OMERACT ultrasound lesions for SpA: results from the DEUS (Defining Enthesitis on Ultrasound in Spondyloarthritis) multicentre study
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 847
OP 857
DO 10.1136/ard-2023-225443
VO 83
IS 7
A1 Di Matteo, Andrea
A1 Smerilli, Gianluca
A1 Di Donato, Stefano
A1 Liu, An Ran
A1 Becciolini, Andrea
A1 Camarda, Federica
A1 Cazenave, Tomas
A1 Cipolletta, Edoardo
A1 Corradini, Davide
A1 de Agustín, Juan José
A1 Destro Castaniti, Giulia Maria
A1 Di Donato, Eleonora
A1 Di Geso, Luca
A1 Duran, Emine
A1 Farisogullari, Bayram
A1 Fornaro, Marco
A1 Francioso, Francesca
A1 Giorgis, Pamela
A1 Granel, Amelia
A1 Hernández-Díaz, Cristina
A1 Horvath, Rudolf
A1 Hurnakova, Jana
A1 Jesus, Diogo
A1 Karadag, Omer
A1 Li, Ling
A1 Marin, Josefina
A1 Martire, María Victoria
A1 Michelena, Xabier
A1 Moscioni, Erica
A1 Muntean, Laura
A1 Piga, Matteo
A1 Rosemffet, Marcos
A1 Rovisco, João
A1 Sahin, Didem
A1 Salaffi, Fausto
A1 Saraiva, Liliana
A1 Scioscia, Crescenzio
A1 Tamas, Maria-Magdalena
A1 Tanimura, Shun
A1 Venetsanopoulou, Aliki
A1 Ventura-Rios, Lucio
A1 Villota, Orlando
A1 Villota-Eraso, Catalina
A1 Voulgari, Paraskevi V
A1 Vukatana, Gentiana
A1 Zacariaz Hereter, Johana
A1 Marzo-Ortega, Helena
A1 Grassi, Walter
A1 Filippucci, Emilio
YR 2024
UL http://ard.bmj.com/content/83/7/847.abstract
AB Objectives To assess, in spondyloarthritis (SpA), the discriminative value of the Outcome Measures in Rheumatology (OMERACT) ultrasound lesions of enthesitis and their associations with clinical features in this population.Methods In this multicentre study involving 20 rheumatology centres, clinical and ultrasound examinations of the lower limb large entheses were performed in 413 patients with SpA (axial SpA and psoriatic arthritis) and 282 disease controls (osteoarthritis and fibromyalgia). ‘Active enthesitis’ was defined as (1) power Doppler (PD) at the enthesis grade ≥1 plus entheseal thickening and/or hypoechoic areas, or (2) PD grade >1 (independent of the presence of entheseal thickening and/or hypoechoic areas).Results In the univariate analysis, all OMERACT lesions except enthesophytes/calcifications showed a significant association with SpA. PD (OR=8.77, 95% CI 4.40 to 19.20, p<0.001) and bone erosions (OR=4.75, 95% CI 2.43 to 10.10, p<0.001) retained this association in the multivariate analysis. Among the lower limb entheses, only the Achilles tendon was significantly associated with SpA (OR=1.93, 95% CI 1.30 to 2.88, p<0.001) in the multivariate analyses. Active enthesitis showed a significant association with SpA (OR=9.20, 95% CI 4.21 to 23.20, p<0.001), and unlike the individual OMERACT ultrasound lesions it was consistently associated with most clinical measures of SpA disease activity and severity in the regression analyses.Conclusions This large multicentre study assessed the value of different ultrasound findings of enthesitis in SpA, identifying the most discriminative ultrasound lesions and entheseal sites for SpA. Ultrasound could differentiate between SpA-related enthesitis and other forms of entheseal pathology (ie, mechanical enthesitis), thus improving the assessment of entheseal involvement in SpA.Data are available upon reasonable request.