PT  - JOURNAL ARTICLE
AU  - Christian Dejaco
AU  - Cristina Ponte
AU  - Sara Monti
AU  - Davide Rozza
AU  - Carlo Alberto Scirè
AU  - Lene Terslev
AU  - George A W Bruyn
AU  - Dennis Boumans
AU  - Wolfgang Hartung
AU  - Alojzija Hočevar
AU  - Marcin Milchert
AU  - Uffe Møller Døhn
AU  - Chetan B Mukhtyar
AU  - Markus Aschwanden
AU  - Philipp Bosch
AU  - Dario Camellino
AU  - Stavros Chrysidis
AU  - Giovanni Ciancio
AU  - Maria Antonietta D’Agostino
AU  - Thomas Daikeler
AU  - Bhaskar Dasgupta
AU  - Eugenio De Miguel
AU  - Andreas P Diamantopoulos
AU  - Christina Duftner
AU  - Ana Agueda
AU  - Ulrich Fredberg
AU  - Petra Hanova
AU  - Ib Tønder Hansen
AU  - Ellen-Margrethe Hauge
AU  - Annamaria Iagnocco
AU  - Nevsun Inanc
AU  - Aaron Juche
AU  - Rositsa Karalilova
AU  - Toshio Kawamoto
AU  - Kresten Krarup Keller
AU  - Helen Isobel Keen
AU  - Tanaz A Kermani
AU  - Minna J. Kohler
AU  - Matthew Koster
AU  - Raashid Ahmed Luqmani
AU  - Pierluigi Macchioni
AU  - Sarah Louise Mackie
AU  - Esperanza Naredo
AU  - Berit Dalsgaard Nielsen
AU  - Michihiro Ogasawara
AU  - Carlos Pineda
AU  - Valentin Sebastian Schäfer
AU  - Luca Seitz
AU  - Alessandro Tomelleri
AU  - Karina D Torralba
AU  - Kornelis S M van der Geest
AU  - Kenneth J Warrington
AU  - Wolfgang A Schmidt
TI  - The provisional OMERACT ultrasonography score for giant cell arteritis
AID  - 10.1136/ard-2022-223367
DP  - 2023 Apr 01
TA  - Annals of the Rheumatic Diseases
PG  - 556--564
VI  - 82
IP  - 4
4099  - http://ard.bmj.com/content/82/4/556.short
4100  - http://ard.bmj.com/content/82/4/556.full
SO  - Ann Rheum Dis2023 Apr 01; 82
AB  - Objectives To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties.Methods The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima–media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24.Results Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72–0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from −1.19 to −2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corrcoeff 0.37–0.48).Conclusion We developed a provisional OGUS for potential use in clinical trials.Data are available upon reasonable request.