RT Journal Article
SR Electronic
T1 Colchicine prophylaxis is associated with fewer gout flares after COVID-19 vaccination
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 1189
OP 1193
DO 10.1136/annrheumdis-2022-222199
VO 81
IS 8
A1 Jie Lu
A1 Yuwei He
A1 Robert Terkeltaub
A1 Mingshu Sun
A1 Zijing Ran
A1 Xinmiao Xu
A1 Can Wang
A1 Xinde Li
A1 Shuhui Hu
A1 Xiaomei Xue
A1 Fei Yan
A1 Hui Zhang
A1 Huiyong Yin
A1 Yongyong Shi
A1 Nicola Dalbeth
A1 Changgui Li
YR 2022
UL http://ard.bmj.com/content/81/8/1189.abstract
AB Objectives COVID-19 vaccination often triggers a constellation of transitory inflammatory symptoms. Gout is associated with several comorbidities linked to poor outcomes in COVID-19, and gout flares can be triggered by some vaccinations. We analysed the risk of gout flares in the first 3 months after COVID-19 vaccination with inactivated virus, and whether colchicine can prevent gout flares following post-COVID-19 vaccination.Methods A clinical delivery population-based cross-sectional study was conducted in the Gout Clinic at the Affiliated Hospital of Qingdao University between February and October 2021. Study participants were selected using a systematic random sampling technique among follow-up patients with gout. We collected data, including vaccinations and potential risk factors, using a combination of interviews, health QR codes and medical records. Logistic regression was used to adjust for covariates.Results We enrolled 549 gout participants (median age 39 years, 84.2% vaccinated). For the 462 patients who received COVID-19 vaccine, 203 (43.9%) developed at least one gout flare in the 3 months after vaccination. Most of these flares were experienced within 1 month after the first (99/119 (83.2%)) or second (70/115 (60.9%)) dose of vaccine. Compared with unvaccinated participants, COVID-19 vaccination was associated with higher odds of gout flare within 3 months (adjusted OR 6.02; 95% CI 3.00 to 12.08). Colchicine use was associated with 47% less likelihood of postvaccine gout flare.Conclusion COVID-19 vaccination was associated with increased odds of gout flare, which developed mainly in month 1 after each vaccine dose, and was negatively associated with colchicine prophylaxis.Data are available on reasonable request. Not applicable.