TY - JOUR T1 - OP0211 PATERNAL INFLAMMATORY ARTHRITIS IS ASSOCIATED WITH A HIGHER RISK OF MISCARRIAGES: RESULTS OF A LARGE MULTICENTER STUDY (IFAME-FERTILITY) JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 127 LP - 127 DO - 10.1136/annrheumdis-2021-eular.1732 VL - 80 IS - Suppl 1 AU - L. F. Perez-Garcia AU - E. Röder AU - R. Goekoop AU - M. R. Kok AU - P. Kok AU - H. T. Smeele AU - I. Tchetverikov AU - A. Van der Helm - van Mil AU - J. H. Van der Kaap AU - B. Krijthe AU - R. Dolhain Y1 - 2021/06/01 UR - http://ard.bmj.com/content/80/Suppl_1/127.1.abstract N2 - Background: The effect of inflammatory arthritis (IA) on pregnancy outcomes has been studied mainly in women. Paternal older age, sperm DNA integrity and certain genetic defects have been associated with worse pregnancy outcomes (1). However, pregnancy outcomes of partners of men with IA have never been studied.Objectives: To describe the pregnancy characteristics and outcomes of partners of men diagnosed with IA.Methods: We performed a multicenter cross-sectional retrospective study conducted in eight Dutch hospitals. Men with IA (Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA) and Spondyloarthritis (SpA)) who were over 40 years old and indicated that their family size was complete were invited to participate. Participants completed a digital questionnaire that included pregnancy-related questions and questions regarding their demographic and clinical information. To analyze the impact of IA on pregnancy outcomes, pregnancies were classified into two groups; pregnancies that occurred after diagnosis of IA and before the diagnosis of IA.Results: In total 628 male participants diagnosed with IA were included. 408 men reported 897 singleton pregnancies that resulted in 794 live births. Regarding pregnancy characteristics, pregnancies conceived after diagnosis of IA had a higher mean paternal and maternal age at conception and a lower rate of spontaneous pregnancies (90.91 vs 96.60%, p=<0.005) (See Table 1). With regards to pregnancy outcomes, pregnancies conceived after receiving the diagnosis of IA had a lower rate of live births (86.36% and 89.22%, p=0.053) and a significant higher rate of miscarriages (12.27 vs 7.53%, p=<0.05). After correcting for maternal age and year of pregnancy, pregnancies conceived after the diagnosis of IA had a higher risk of miscarriages (OR 1.71 [CI 1.04-2.81], p<0.05). No statistically significant differences between the two groups were reported for the rates of abortions, preterm births and pregnancy complications.View this table:Table 1. Pregnancy characteristics and outcomes.Conclusion: This is the largest study to describe the pregnancy characteristics and outcomes of partners of men diagnosed with IA and the first to demonstrate that paternal IA is associated with a higher risk of miscarriage. Prospective studies are needed to corroborate these findings.References: [1]Ibrahim Y, Johnstone E. The male contribution to recurrent pregnancy loss. Translational andrology and urology. 2018;7(Suppl 3):S317-S27.Acknowledgements: The authors would like to acknowledge Ron Buijs, data manager of the Department of Rheumatology of the Erasmus MC, for his technical support with regards to data collection.Disclosure of Interests: Luis Fernando Perez-Garcia Consultant of: Galapagos, Esther Röder: None declared, Robbert Goekoop: None declared, Marc R Kok Consultant of: Roche, Grant/research support from: Roche, Petra Kok: None declared, Hieronymus TW Smeele: None declared, Ilja Tchetverikov: None declared, Annette van der Helm - van Mil: None declared, J.H. van der Kaap: None declared, Bouwe Krijthe: None declared, Radboud Dolhain Speakers bureau: Abbvie, UCB, Genzyme, Novartis, Consultant of: Galapagos, Grant/research support from: UCB ER -