RT Journal Article
SR Electronic
T1 Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 1333
OP 1339
DO 10.1136/annrheumdis-2020-217162
VO 79
IS 10
A1 Sindhu R Johnson
A1 Ralph Brinks
A1 Karen H Costenbader
A1 David Daikh
A1 Marta Mosca
A1 Rosalind Ramsey-Goldman
A1 Josef S Smolen
A1 David Wofsy
A1 Dimitrios T Boumpas
A1 Diane L Kamen
A1 David Jayne
A1 R Cervera
A1 Nathalie Costedoat-Chalumeau
A1 Betty Diamond
A1 Dafna D Gladman
A1 Bevra Hahn
A1 Falk Hiepe
A1 Søren Jacobsen
A1 Dinesh Khanna
A1 Kirsten Lerstrøm
A1 Elena Massarotti
A1 Joseph McCune
A1 Guillermo Ruiz-Irastorza
A1 Jorge Sanchez-Guerrero
A1 Matthias Schneider
A1 Murray Urowitz
A1 George Bertsias
A1 Bimba F Hoyer
A1 Nicolai Leuchten
A1 Chiara Tani
A1 Sara K Tedeschi
A1 Zahi Touma
A1 Gabriela Schmajuk
A1 Branimir Anic
A1 Florence Assan
A1 Tak Mao Chan
A1 Ann Elaine Clarke
A1 Mary K Crow
A1 László Czirják
A1 Andrea Doria
A1 Winfried B Graninger
A1 Bernadett Halda-Kiss
A1 Sarfaraz Hasni
A1 Peter M Izmirly
A1 Michelle Jung
A1 Gábor Kumánovics
A1 Xavier Mariette
A1 Ivan Padjen
A1 José M Pego-Reigosa
A1 Juanita Romero-Diaz
A1 Íñigo Rúa-Figueroa
A1 Raphaèle Seror
A1 Georg H Stummvoll
A1 Yoshiya Tanaka
A1 Maria G Tektonidou
A1 Carlos Vasconcelos
A1 Edward M Vital
A1 D J Wallace
A1 Sule Yavuz
A1 Pier Luigi Meroni
A1 Marvin J Fritzler
A1 Ray Naden
A1 Thomas Dörner
A1 Martin Aringer
YR 2020
UL http://ard.bmj.com/content/79/10/1333.abstract
AB Objectives The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 Classification Criteria for systemic lupus erythematosus (SLE) have been validated with high sensitivity and specificity. We evaluated the performance of the new criteria with regard to disease duration, sex and race/ethnicity, and compared its performance against the Systemic Lupus International Collaborating Clinics (SLICC) 2012 and ACR 1982/1997 criteria.Methods Twenty-one SLE centres from 16 countries submitted SLE cases and mimicking controls to form the validation cohort. The sensitivity and specificity of the EULAR/ACR 2019, SLICC 2012 and ACR 1982/1997 criteria were evaluated.Results The cohort consisted of female (n=1098), male (n=172), Asian (n=118), black (n=68), Hispanic (n=124) and white (n=941) patients; with an SLE duration of 1 to <3 years (n=196) and ≥5 years (n=879). Among patients with 1 to <3 years disease duration, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 81%). The EULAR/ACR criteria performed well in men (sensitivity 93%, specificity 96%) and women (sensitivity 97%, specificity 94%). Among women, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 83%) and better specificity than the SLICC criteria (94% vs 82%). Among white patients, the EULAR/ACR criteria had better sensitivity than the ACR criteria (95% vs 83%) and better specificity than the SLICC criteria (94% vs 83%). The EULAR/ACR criteria performed well among black patients (sensitivity of 98%, specificity 100%), and had better sensitivity than the ACR criteria among Hispanic patients (100% vs 86%) and Asian patients (97% vs 77%).Conclusions The EULAR/ACR 2019 criteria perform well among patients with early disease, men, women, white, black, Hispanic and Asian patients. These criteria have superior sensitivity than the ACR criteria and/or superior specificity than the SLICC criteria across many subgroups.