@article {Tektonidou1296, author = {Maria G Tektonidou and Laura Andreoli and Marteen Limper and Zahir Amoura and Ricard Cervera and Nathalie Costedoat-Chalumeau and Maria Jose Cuadrado and Thomas D{\"o}rner and Raquel Ferrer-Oliveras and Karen Hambly and Munther A Khamashta and Judith King and Francesca Marchiori and Pier Luigi Meroni and Marta Mosca and Vittorio Pengo and Luigi Raio and Guillermo Ruiz-Irastorza and Yehuda Shoenfeld and Ljudmila Stojanovich and Elisabet Svenungsson and Denis Wahl and Angela Tincani and Michael M Ward}, title = {EULAR recommendations for the management of antiphospholipid syndrome in adults}, volume = {78}, number = {10}, pages = {1296--1304}, year = {2019}, doi = {10.1136/annrheumdis-2019-215213}, publisher = {BMJ Publishing Group Ltd}, abstract = {The objective was to develop evidence-based recommendations for the management of antiphospholipid syndrome (APS) in adults. Based on evidence from a systematic literature review and expert opinion, overarching principles and recommendations were formulated and voted. High-risk antiphospholipid antibody (aPL) profile is associated with greater risk for thrombotic and obstetric APS. Risk modification includes screening for and management of cardiovascular and venous thrombosis risk factors, patient education about treatment adherence, and lifestyle counselling. Low-dose aspirin (LDA) is recommended for asymptomatic aPL carriers, patients with systemic lupus erythematosus without prior thrombotic or obstetric APS, and non-pregnant women with a history of obstetric APS only, all with high-risk aPL profiles. Patients with APS and first unprovoked venous thrombosis should receive long-term treatment with vitamin K antagonists (VKA) with a target international normalised ratio (INR) of 2{\textendash}3. In patients with APS with first arterial thrombosis, treatment with VKA with INR 2{\textendash}3 or INR 3{\textendash}4 is recommended, considering the individual{\textquoteright}s bleeding/thrombosis risk. Rivaroxaban should not be used in patients with APS with triple aPL positivity. For patients with recurrent arterial or venous thrombosis despite adequate treatment, addition of LDA, increase of INR target to 3{\textendash}4 or switch to low molecular weight heparin may be considered. In women with prior obstetric APS, combination treatment with LDA and prophylactic dosage heparin during pregnancy is recommended. In patients with recurrent pregnancy complications, increase of heparin to therapeutic dose, addition of hydroxychloroquine or addition of low-dose prednisolone in the first trimester may be considered. These recommendations aim to guide treatment in adults with APS. High-quality evidence is limited, indicating a need for more research.}, issn = {0003-4967}, URL = {https://ard.bmj.com/content/78/10/1296}, eprint = {https://ard.bmj.com/content/78/10/1296.full.pdf}, journal = {Annals of the Rheumatic Diseases} }