TY - JOUR T1 - Hydroxychloroquine dosing in systemic lupus erythematosus: response to ‘Letter in response to the 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus by Fanouriakis <em>et al’</em> by Costedoat-Chalumeau <em>et al</em> JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis DO - 10.1136/annrheumdis-2019-215615 SP - annrheumdis-2019-215615 AU - Antonis Fanouriakis AU - George Bertsias AU - Dimitrios T Boumpas Y1 - 2019/06/14 UR - http://ard.bmj.com/content/early/2019/06/14/annrheumdis-2019-215615.abstract N2 - We thank Drs Costedoat-Chalumeau, Isenberg and Petri for their interest and insightful comments regarding hydroxychloroquine (HCQ) dosing in systemic lupus erythematosus (SLE).1 The authors outline three major arguments against recommending a lower daily dose for HCQ: (1) the lower dose of 5 mg/kg real weight/day has not proven equal efficacy with the previous 6.5 mg/kg/day, (2) the patient population of the studies that suggest higher rates of HCQ-retinopathy (older patients, mostly with rheumatoid arthritis) does not correspond to the average patient with lupus and (3) established low adherence rates to HCQ reported in some studies, if combined with a lower prescribed dose, may potentially lead to HCQ … ER -