@article {Tedeschi634, author = {Sara K Tedeschi and Sindhu R Johnson and Dimitrios T Boumpas and David Daikh and Thomas D{\"o}rner and Betty Diamond and S{\o}ren Jacobsen and David Jayne and Diane L Kamen and W Joseph McCune and Marta Mosca and Rosalind Ramsey-Goldman and Guillermo Ruiz-Irastorza and Matthias Schneider and Murray Urowitz and David Wofsy and Josef S Smolen and Raymond P Naden and Martin Aringer and Karen H Costenbader}, title = {Multicriteria decision analysis process to develop new classification criteria for systemic lupus erythematosus}, volume = {78}, number = {5}, pages = {634--640}, year = {2019}, doi = {10.1136/annrheumdis-2018-214685}, publisher = {BMJ Publishing Group Ltd}, abstract = {European League Against Rheumatism and are jointly supporting multiphase development of systemic lupus erythematosus (SLE) classification criteria based on weighted criteria and a continuous probability scale. Prior steps included item generation, item reduction and hierarchical organisation of candidate criteria using an evidence-based approach. Our objectives were to determine relative weights using multicriteria decision analysis (MCDA) and to set a provisional threshold score for SLE classification. An SLE Expert Panel (8 European, 9 North American) submitted 164 real, unique cases with a wide range of SLE probability in a standardised format. Using the candidate criteria, experts scored and rank-ordered 20 representative cases. At an in-person meeting, experts reviewed inter-rater reliability of scoring, further refined criteria definitions and participated in an MCDA exercise. Based on expert consensus decisions on pairwise comparisons of criteria, 1000minds software calculated criteria weights and rank-ordered the remaining 144 cases based on their additive scores. The score of the lowest-ranked case for which complete expert consensus was achieved defined the provisional threshold classification score. Inter-rater reliability of scoring cases with the candidate criteria was good. MCDA involved 74 pairwise decisions and was repeated for the arthritis and mucocutaneous domains when the initial ranking of some cases did not match expert opinion. After criteria weights and additive scores were recalculated once, experts reached consensus for SLE classification for all cases scoring\>83. Using an iterative process, the candidate criteria definitions were refined, preliminary weights were calculated and a provisional threshold score for SLE classification was determined.}, issn = {0003-4967}, URL = {https://ard.bmj.com/content/78/5/634}, eprint = {https://ard.bmj.com/content/78/5/634.full.pdf}, journal = {Annals of the Rheumatic Diseases} }