TY - JOUR T1 - HLA class I and II alleles in susceptibility to ankylosing spondylitis JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 66 LP - 73 DO - 10.1136/annrheumdis-2018-213779 VL - 78 IS - 1 AU - John D Reveille AU - Xiaodong Zhou AU - MinJae Lee AU - Michael H Weisman AU - Lin Yi AU - Lianne S Gensler AU - Hejian Zou AU - Michael M Ward AU - Mariko L Ishimori AU - Thomas J Learch AU - Dongyi He AU - Mohammad H Rahbar AU - Jiucun Wang AU - Matthew A Brown Y1 - 2019/01/01 UR - http://ard.bmj.com/content/78/1/66.abstract N2 - Objective To examine associations of HLA class I and class II alleles with ankylosing spondylitis (AS) in three cohorts of patients of European, Asian and African ancestry.Methods HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1 and HLA-DPB1 alleles were genotyped in 1948 unrelated white and 67 African-American patients with AS from the Prospective Study of Outcomes in Ankylosing Spondylitis cohort, the North American Spondylitis Consortium and Australo-Anglo-American Spondyloarthritis Consortium, 990 white and 245 African-American Controls and HLA-B alleles in 442 Han Chinese patients with AS and 346 controls from Shanghai and Gansu, China. In addition to the case:control analyses, HLA-B*27-negative patients with AS were analysed separately, and logistic regression and ‘relative predispositional effects’ (RPE) analyses were carried out to control for the major effect of HLA-B*27 on disease susceptibility.Results Although numerous associations were seen between HLA alleles and AS in whites, among HLA-B*27-negative patients with AS , positive associations were seen with HLA-A*29, B*38, B*49, B*52, DRB1*11 and DPB1*03:01 and negative associations with HLA-B*07, HLA-B*57, HLA-DRB1*15:01, HLA-DQB1*02:01 and HLA -DQB1*06:02. Additional associations with HLA-B*14 and B*40 (B60) were observed via RPE analysis, which excludes the HLA-B*27 alleles. The increased frequency of HLA-B*40:01 and decreased frequency of HLA-B*07 was also seen in Han Chinese and African-Americans with AS. HLA-B*08 was decreased in whites with acute anterior uveitis.Conclusions These data, analysing the largest number of patients with AS examined to date in three ethnic groups, confirm that other HLA class I and II alleles other than HLA-B*27 to be operative in AS predisposition. ER -