RT Journal Article
SR Electronic
T1 2018 update of the EULAR recommendations for the management of Behçet’s syndrome
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP annrheumdis-2018-213225
DO 10.1136/annrheumdis-2018-213225
A1 Gulen Hatemi
A1 Robin Christensen
A1 Dongsik Bang
A1 Bahram Bodaghi
A1 Aykut Ferhat Celik
A1 Farida Fortune
A1 Julien Gaudric
A1 Ahmet Gul
A1 Ina Kötter
A1 Pietro Leccese
A1 Alfred Mahr
A1 Robert Moots
A1 Yesim Ozguler
A1 Jutta Richter
A1 David Saadoun
A1 Carlo Salvarani
A1 Francesco Scuderi
A1 Petros P Sfikakis
A1 Aksel Siva
A1 Miles Stanford
A1 Ilknur Tugal-Tutkun
A1 Richard West
A1 Sebahattin Yurdakul
A1 Ignazio Olivieri
A1 Hasan Yazici
YR 2018
UL http://ard.bmj.com/content/early/2018/04/06/annrheumdis-2018-213225.abstract
AB Several new treatment modalities with different mechanisms of action have been studied in patients with Behçet’s syndrome (BS). The aim of the current effort was to update the recommendations in the light of these new data under the auspices of the European League Against Rheumatism (EULAR) Standing Committee for Clinical Affairs. A task force was formed that included BS experts from different specialties including internal medicine, rheumatology, ophthalmology, dermatology, neurology, gastroenterology, oral health medicine and vascular surgery, along with a methodologist, a health professional, two patients and two fellows in charge of the systematic literature search. Research questions were determined using a Delphi approach. EULAR standardised operating procedures was used as the framework. Results of the systematic literature review were presented to the task force during a meeting. The former recommendations were modified or new recommendations were formed after thorough discussions followed by voting. The recommendations on the medical management of mucocutaneous, joint, eye, vascular, neurological and gastrointestinal involvement of BS were modified; five overarching principles and a new recommendation about the surgical management of vascular involvement were added. These updated, evidence-based recommendations are intended to help physicians caring for patients with BS. They also attempt to highlight the shortcomings of the available clinical research with the aim of proposing an agenda for further research priorities.