RT Journal Article SR Electronic T1 Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis JF Annals of the Rheumatic Diseases JO Ann Rheum Dis FD BMJ Publishing Group Ltd and European League Against Rheumatism SP 48 OP 54 DO 10.1136/annrheumdis-2017-211735 VO 77 IS 1 A1 Crowson, Cynthia S A1 Rollefstad, Silvia A1 Ikdahl, Eirik A1 Kitas, George D A1 van Riel, Piet L C M A1 Gabriel, Sherine E A1 Matteson, Eric L A1 Kvien, Tore K A1 Douglas, Karen A1 Sandoo, Aamer A1 Arts, Elke A1 Wållberg-Jonsson, Solveig A1 Innala, Lena A1 Karpouzas, George A1 Dessein, Patrick H A1 Tsang, Linda A1 El-Gabalawy, Hani A1 Hitchon, Carol A1 Ramos, Virginia Pascual A1 Yáñez, Irazú Contreras A1 Sfikakis, Petros P A1 Zampeli, Evangelia A1 Gonzalez-Gay, Miguel A A1 Corrales, Alfonso A1 Laar, Mart van de A1 Vonkeman, Harald E A1 Meek, Inger A1 Semb, Anne Grete A1 YR 2018 UL http://ard.bmj.com/content/77/1/48.abstract AB Objectives Patients with rheumatoid arthritis (RA) have an excess risk of cardiovascular disease (CVD). We aimed to assess the impact of CVD risk factors, including potential sex differences, and RA-specific variables on CVD outcome in a large, international cohort of patients with RA.Methods In 13 rheumatology centres, data on CVD risk factors and RA characteristics were collected at baseline. CVD outcomes (myocardial infarction, angina, revascularisation, stroke, peripheral vascular disease and CVD death) were collected using standardised definitions.Results 5638 patients with RA and no prior CVD were included (mean age: 55.3 (SD: 14.0) years, 76% women). During mean follow-up of 5.8 (SD: 4.4) years, 148 men and 241 women developed a CVD event (10-year cumulative incidence 20.9% and 11.1%, respectively). Men had a higher burden of CVD risk factors, including increased blood pressure, higher total cholesterol and smoking prevalence than women (all p<0.001). Among the traditional CVD risk factors, smoking and hypertension had the highest population attributable risk (PAR) overall and among both sexes, followed by total cholesterol. The PAR for Disease Activity Score and for seropositivity were comparable in magnitude to the PAR for lipids. A total of 70% of CVD events were attributable to all CVD risk factors and RA characteristics combined (separately 49% CVD risk factors and 30% RA characteristics).Conclusions In a large, international cohort of patients with RA, 30% of CVD events were attributable to RA characteristics. This finding indicates that RA characteristics play an important role in efforts to reduce CVD risk among patients with RA.