TY - JOUR T1 - Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 48 LP - 54 DO - 10.1136/annrheumdis-2017-211735 VL - 77 IS - 1 AU - Cynthia S Crowson AU - Silvia Rollefstad AU - Eirik Ikdahl AU - George D Kitas AU - Piet L C M van Riel AU - Sherine E Gabriel AU - Eric L Matteson AU - Tore K Kvien AU - Karen Douglas AU - Aamer Sandoo AU - Elke Arts AU - Solveig Wållberg-Jonsson AU - Lena Innala AU - George Karpouzas AU - Patrick H Dessein AU - Linda Tsang AU - Hani El-Gabalawy AU - Carol Hitchon AU - Virginia Pascual Ramos AU - Irazú Contreras Yáñez AU - Petros P Sfikakis AU - Evangelia Zampeli AU - Miguel A Gonzalez-Gay AU - Alfonso Corrales AU - Mart van de Laar AU - Harald E Vonkeman AU - Inger Meek AU - Anne Grete Semb A2 - , Y1 - 2018/01/01 UR - http://ard.bmj.com/content/77/1/48.abstract N2 - Objectives Patients with rheumatoid arthritis (RA) have an excess risk of cardiovascular disease (CVD). We aimed to assess the impact of CVD risk factors, including potential sex differences, and RA-specific variables on CVD outcome in a large, international cohort of patients with RA.Methods In 13 rheumatology centres, data on CVD risk factors and RA characteristics were collected at baseline. CVD outcomes (myocardial infarction, angina, revascularisation, stroke, peripheral vascular disease and CVD death) were collected using standardised definitions.Results 5638 patients with RA and no prior CVD were included (mean age: 55.3 (SD: 14.0) years, 76% women). During mean follow-up of 5.8 (SD: 4.4) years, 148 men and 241 women developed a CVD event (10-year cumulative incidence 20.9% and 11.1%, respectively). Men had a higher burden of CVD risk factors, including increased blood pressure, higher total cholesterol and smoking prevalence than women (all p<0.001). Among the traditional CVD risk factors, smoking and hypertension had the highest population attributable risk (PAR) overall and among both sexes, followed by total cholesterol. The PAR for Disease Activity Score and for seropositivity were comparable in magnitude to the PAR for lipids. A total of 70% of CVD events were attributable to all CVD risk factors and RA characteristics combined (separately 49% CVD risk factors and 30% RA characteristics).Conclusions In a large, international cohort of patients with RA, 30% of CVD events were attributable to RA characteristics. This finding indicates that RA characteristics play an important role in efforts to reduce CVD risk among patients with RA. ER -