TY - JOUR T1 - Amino-bisphosphonates, γδT cells, and their roles in Rheumatoid Arthritis JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis DO - 10.1136/annrheumdis-2017-212569 SP - annrheumdis-2017-212569 AU - Wen-Xiu Mo AU - Shan-Shan Yin AU - Hua Chen AU - Xuan Zhang Y1 - 2017/11/17 UR - http://ard.bmj.com/content/early/2017/11/17/annrheumdis-2017-212569.abstract N2 - We thank Dr Rossini and colleagues1 for their interesting comments on our manuscript.2Aminobisphosphonates (N-BPs), the analogue of isopentenyl pyrophosphate, promote the activation and proliferation of peripheral γδ T cells, specifically Vγ9/Vδ2 T cells,3 which are the cells we showed that play an important role in the pathogenesis of rheumatoid arthritis (RA).2 We fully agree that γδ T cells are one of the major factors that may contribute to N-BPs-related acute phase response … ER -