RT Journal Article
SR Electronic
T1 Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sjögren's syndrome with other sets of criteria in Japanese patients
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 1980
OP 1985
DO 10.1136/annrheumdis-2016-210758
VO 76
IS 12
A1 Tsuboi, Hiroto
A1 Hagiwara, Shinya
A1 Asashima, Hiromitsu
A1 Takahashi, Hiroyuki
A1 Hirota, Tomoya
A1 Noma, Hisashi
A1 Umehara, Hisanori
A1 Kawakami, Atsushi
A1 Nakamura, Hideki
A1 Sano, Hajime
A1 Tsubota, Kazuo
A1 Ogawa, Yoko
A1 Takamura, Etsuko
A1 Saito, Ichiro
A1 Inoue, Hiroko
A1 Nakamura, Seiji
A1 Moriyama, Masafumi
A1 Takeuchi, Tsutomu
A1 Tanaka, Yoshiya
A1 Hirata, Shintaro
A1 Mimori, Tsuneyo
A1 Matsumoto, Isao
A1 Sumida, Takayuki
YR 2017
UL http://ard.bmj.com/content/76/12/1980.abstract
AB Objectives To compare the performance of the new 2016 American College of Rheumatology (ACR)-European League Against Rheumatism (EULAR) classification criteria for primary Sjögren's syndrome (SS) with 1999 revised Japanese Ministry of Health criteria for diagnosis of SS (JPN), 2002 American-European Consensus Group classification criteria for SS (AECG) and 2012 ACR classification criteria for SS (ACR) in Japanese patients.Methods The study subjects were 499 patients with primary SS (pSS) or suspected pSS who were followed up in June 2012 at 10 hospitals in Japan. All patients had been assessed for all four criteria of JPN (pathology, oral, ocular, anti-SS-A/SS-B antibodies). The clinical diagnosis by the physician in charge was set as the ‘gold standard’.Results pSS was diagnosed in 302 patients and ruled out in 197 patients by the physician in charge. The sensitivity of the ACR-EULAR criteria in the diagnosis of pSS (95.4%) was higher than those of the JPN, AECG and ACR (82.1%, 89.4% and 79.1%, respectively), while the specificity of the ACR-EULAR (72.1%) was lower than those of the three sets (90.9%, 84.3% and 84.8%, respectively). The differences of sensitivities and specificities between the ACR-EULAR and other three sets of criteria were statistically significant (p<0.001). Eight out of 302 patients with pSS and 11 cases out of 197 non-pSS cases satisfied only the ACR-EULAR criteria, compared with none of the other three sets.Conclusions The ACR-EULAR criteria had significantly higher sensitivity and lower specificity in diagnosis of pSS, compared with the currently available three sets of criteria.