PT - JOURNAL ARTICLE AU - Maxime Dougados AU - Alexandre Sepriano AU - Anna Molto AU - Miranda van Lunteren AU - Sofia Ramiro AU - Manouk de Hooge AU - Rosaline van den Berg AU - Victoria Navarro Compan AU - Christophe Demattei AU - Robert Landewé AU - Désirée van der Heijde TI - Sacroiliac radiographic progression in recent onset axial spondyloarthritis: the 5-year data of the DESIR cohort AID - 10.1136/annrheumdis-2017-211596 DP - 2017 Nov 01 TA - Annals of the Rheumatic Diseases PG - 1823--1828 VI - 76 IP - 11 4099 - http://ard.bmj.com/content/76/11/1823.short 4100 - http://ard.bmj.com/content/76/11/1823.full SO - Ann Rheum Dis2017 Nov 01; 76 AB - Objective To estimate sacroiliac joint radiographic (X-SIJ) progression in patients with axial spondyloarthritis (axSpA) and to evaluate the effects of inflammation on MRI (MRI-SIJ) on X-SIJ progression.Methods X-SIJ and MRI-SIJ at baseline and after 2 and 5 years in patients with recent onset axSpA from the DESIR cohort were scored by three central readers. Progression was defined as (1) the shift from non-radiographic (nr) to radiographic (r) sacroiliitis (by modified New York (mNY) criteria) or alternative criteria, (2) a change of at least one grade or (3) a change of at least one grade but ignoring a change from grade 0 to 1. The effects of baseline inflammation on MRI-SIJ on 5-year X-SIJ damage (mNY) were tested by generalised estimating equations.Results In 416 patients with pairs of baseline and 5-year X-SIJ present, net progression occurred in 5.1% (1), 13.0% (2) and 10.3% (3) respectively, regarding a shift from nr-axSpA to r-axSpA (1), a change of at least one grade (2) or a change of at least one grade but ignoring a change from grade 0 to 1 (3). Baseline MRI-SIJ predicted structural damage after 5 years in human leukocyte antigen-B27 (HLA-B27) positive (OR 5.39 (95% CI 3.25 to 8.94)) and in HLA-B27 negative (OR 2.16 (95% CI 1.04 to 4.51)) patients.Conclusions Five-year progression of X-SIJ damage in patients with recent onset axSpA is limited but present beyond measurement error. Baseline MRI-SIJ inflammation drives 5-year radiographic changes.