PT  - JOURNAL ARTICLE
AU  - Pilar Brito-Zerón
AU  - Nihan Acar-Denizli
AU  - Margit Zeher
AU  - Astrid Rasmussen
AU  - Raphaele Seror
AU  - Elke Theander
AU  - Xiaomei Li
AU  - Chiara Baldini
AU  - Jacques-Eric Gottenberg
AU  - Debashish Danda
AU  - Luca Quartuccio
AU  - Roberta Priori
AU  - Gabriela Hernandez-Molina
AU  - Aike A Kruize
AU  - Valeria Valim
AU  - Marika Kvarnstrom
AU  - Damien Sene
AU  - Roberto Gerli
AU  - Sonja Praprotnik
AU  - David Isenberg
AU  - Roser Solans
AU  - Maureen Rischmueller
AU  - Seung-Ki Kwok
AU  - Gunnel Nordmark
AU  - Yasunori Suzuki
AU  - Roberto Giacomelli
AU  - Valerie Devauchelle-Pensec
AU  - Michele Bombardieri
AU  - Benedikt Hofauer
AU  - Hendrika Bootsma
AU  - Johan G Brun
AU  - Guadalupe Fraile
AU  - Steven E Carsons
AU  - Tamer A Gheita
AU  - Jacques Morel
AU  - Cristina Vollenveider
AU  - Fabiola Atzeni
AU  - Soledad Retamozo
AU  - Ildiko Fanny Horvath
AU  - Kathy Sivils
AU  - Thomas Mandl
AU  - Pulukool Sandhya
AU  - Salvatore De Vita
AU  - Jorge Sanchez-Guerrero
AU  - Eefje van der Heijden
AU  - Virginia Fernandes Moça Trevisani
AU  - Marie Wahren-Herlenius
AU  - Xavier Mariette
AU  - Manuel Ramos-Casals
TI  - Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium
AID  - 10.1136/annrheumdis-2016-209952
DP  - 2017 Jun 01
TA  - Annals of the Rheumatic Diseases
PG  - 1042--1050
VI  - 76
IP  - 6
4099  - http://ard.bmj.com/content/76/6/1042.short
4100  - http://ard.bmj.com/content/76/6/1042.full
SO  - Ann Rheum Dis2017 Jun 01; 76
AB  - Objectives To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis.Methods The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed.Results We included 7748 women (93%) and 562 men (7%), with a mean age at diagnosis of primary SjS of 53 years. Ethnicity data were available for 7884 patients (95%): 6174 patients (78%) were white, 1066 patients (14%) were Asian, 393 patients (5%) were Hispanic, 104 patients (1%) were black/African-American and 147 patients (2%) were of other ethnicities. SjS was diagnosed a mean of 7 years earlier in black/African-American compared with white patients; the female-to-male ratio was highest in Asian patients (27:1) and lowest in black/African-American patients (7:1); the prevalence of sicca symptoms was lowest in Asian patients; a higher frequency of positive salivary biopsy was found in Hispanic and white patients. A north-south gradient was found with respect to a lower frequency of ocular involvement in northern countries for dry eyes and abnormal ocular tests in Europe (OR 0.46 and 0.44, respectively) and Asia (OR 0.18 and 0.49, respectively) compared with southern countries. Higher frequencies of antinuclear antibodies (ANAs) were reported in northern countries in America (OR=1.48) and Asia (OR=3.80) while, in Europe, northern countries had lowest frequencies of ANAs (OR=0.67) and Ro/La (OR=0.69).Conclusions This study provides the first evidence of a strong influence of geolocation and ethnicity on the phenotype of primary SjS at diagnosis.