TY - JOUR T1 - International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 673 LP - 680 DO - 10.1136/annrheumdis-2016-210242 VL - 76 IS - 4 AU - Ana-Maria Orbai AU - Maarten de Wit AU - Philip Mease AU - Judy A Shea AU - Laure Gossec AU - Ying Ying Leung AU - William Tillett AU - Musaab Elmamoun AU - Kristina Callis Duffin AU - Willemina Campbell AU - Robin Christensen AU - Laura Coates AU - Emma Dures AU - Lihi Eder AU - Oliver FitzGerald AU - Dafna Gladman AU - Niti Goel AU - Suzanne Dolwick Grieb AU - Sarah Hewlett AU - Pil Hoejgaard AU - Umut Kalyoncu AU - Chris Lindsay AU - Neil McHugh AU - Bev Shea AU - Ingrid Steinkoenig AU - Vibeke Strand AU - Alexis Ogdie Y1 - 2017/04/01 UR - http://ard.bmj.com/content/76/4/673.abstract N2 - Objective To identify a core set of domains (outcomes) to be measured in psoriatic arthritis (PsA) clinical trials that represent both patients' and physicians' priorities.Methods We conducted (1) a systematic literature review (SLR) of domains assessed in PsA; (2) international focus groups to identify domains important to people with PsA; (3) two international surveys with patients and physicians to prioritise domains; (4) an international face-to-face meeting with patients and physicians using the nominal group technique method to agree on the most important domains; and (5) presentation and votes at the Outcome Measures in Rheumatology (OMERACT) conference in May 2016. All phases were performed in collaboration with patient research partners.Results We identified 39 unique domains through the SLR (24 domains) and international focus groups (34 domains). 50 patients and 75 physicians rated domain importance. During the March 2016 consensus meeting, 12 patients and 12 physicians agreed on 10 candidate domains. Then, 49 patients and 71 physicians rated these domains' importance. Five were important to >70% of both groups: musculoskeletal disease activity, skin disease activity, structural damage, pain and physical function. Fatigue and participation were important to >70% of patients. Patient global and systemic inflammation were important to >70% of physicians. The updated PsA core domain set endorsed by 90% of OMERACT 2016 participants includes musculoskeletal disease activity, skin disease activity, pain, patient global, physical function, health-related quality of life, fatigue and systemic inflammation.Conclusions The updated PsA core domain set incorporates patients' and physicians' priorities and evolving PsA research. Next steps include identifying outcome measures that adequately assess these domains. ER -