TY - JOUR T1 - Subclinical joint inflammation in patients with psoriasis without concomitant psoriatic arthritis: a cross-sectional and longitudinal analysis JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 2068 LP - 2074 DO - 10.1136/annrheumdis-2015-208821 VL - 75 IS - 12 AU - Francesca Faustini AU - David Simon AU - Isabelle Oliveira AU - Arnd Kleyer AU - Judith Haschka AU - Matthias Englbrecht AU - Alan Rodrigues Cavalcante AU - Sebastian Kraus AU - Taiane Ponte Tabosa AU - Camille Figueiredo AU - Axel J Hueber AU - Roland Kocijan AU - Alexander Cavallaro AU - Georg Schett AU - Michael Sticherling AU - Jürgen Rech Y1 - 2016/12/01 UR - http://ard.bmj.com/content/75/12/2068.abstract N2 - Objectives To search for subclinical inflammatory joint disease in patients with psoriasis without psoriatic arthritis (PsA), and to determine whether such changes are associated with the later development of PsA.Methods Eighty-five subjects without arthritis (55 with psoriasis and 30 healthy controls) received high field MRI of the hand. MRI scans were scored for synovitis, osteitis, tenosynovitis and periarticular inflammation according to the PsAMRIS method. Patients with psoriasis additionally received complete clinical investigation, high-resolution peripheral quantitative CT for detecting erosions and enthesiophytes and were followed up for at least 1 year for the development of PsA.Results 47% of patients with psoriasis showed at least one inflammatory lesion on MRI. Synovitis was the most prevalent inflammatory lesion (38%), while osteitis (11%), tenosynovitis (4%) and periarticular inflammation (4%) were less frequent. The mean (±SD) PsAMRIS synovitis score was 3.0±2.5 units. Enthesiophytes and bone erosions were not different between patients with psoriasis with or without inflammatory MRI changes. The risk for developing PsA was as high as 60% if patients had subclinical synovitis and symptoms related to arthralgia, but only 13% if patients had normal MRIs and did not report arthralgia.Conclusions Prevalence of subclinical inflammatory lesions is high in patients with cutaneous psoriasis. Arthralgia in conjunction with MRI synovitis constitutes a high-risk constellation for the development of PsA. ER -