RT Journal Article
SR Electronic
T1 SAT0061 Concurrent Ultrasound-Detected Synovitis and Tenosynovitis Predict Flare in Patients with Rheumatoid Arthritis in Clinical Remission
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 686
OP 686
DO 10.1136/annrheumdis-2016-eular.4747
VO 75
IS Suppl 2
A1 Sakellariou, G.
A1 Bellis, E.
A1 Scirè, C.A.
A1 Carrara, G.
A1 Adinolfi, A.
A1 Bortoluzzi, A.
A1 Batticciotto, A.
A1 Cagnotto, G.
A1 Caprioli, M.
A1 Canzoni, M.
A1 Cavatorta, F.P.
A1 De Lucia, O.
A1 Di Sabatino, V.
A1 Draghessi, A.
A1 Filippou, G.
A1 Farina, I.
A1 Focherini, M.C.
A1 Gabba, A.
A1 Gutierrez, M.
A1 Idolazzi, L.
A1 Luccioli, F.
A1 Macchioni, P.
A1 Massarotti, M.S.
A1 Mastaglio, C.
A1 Menza, L.
A1 Muratore, M.
A1 Parisi, S.
A1 Picerno, V.
A1 Piga, M.
A1 Ramonda, R.
A1 Raffeiner, B.
A1 Rossi, D.
A1 Rossi, S.
A1 Rossini, P.
A1 Scioscia, C.
A1 Venditti, C.
A1 Volpe, A.
A1 Matucci-Cerinic, M.
A1 Iagnocco, A.
YR 2016
UL http://ard.bmj.com/content/75/Suppl_2/686.2.abstract
AB Background Subclinical synovial inflammation detected by ultrasonography (US) in patients with rheumatoid arthritis (RA) in clinical remission relates to disease flare. The impact of tenosynovitis in this context is not known.Objectives To evaluate the association between US-detected tenosynovitis and synovitis in RA patients in clinical remission and flare over 12-months.Methods STARTER is a multicentre cohort study of the US Study Group of the Italian Society for Rheumatology. Participants were selected on the basis of a reliability exercise and the availability of high-end equipment. Patients with RA in clinical remission underwent clinical evaluation and US synovitis (-S) and tenosynovitis (-T) were assessed categorically for Grey Scale (GS) and power Doppler (PD) at 11 joints, extensor and flexor tendons in both hands and wrists. Patients were seen at 6 and 12 months. Flare within 12 months was defined as increase of >1.2 or >0.6 if final DAS28>3.2. The relationship between the presence of GS-T/-S, PD-T/-S was evaluated by logistic models, presented as odds ratios (OR) and 95% confidence interval (CI), adjusted for pre-specified confounders.Results 361 patients (72.3% f, mean age (sd) 56.1 (13.3), median disease duration (IQR) 7.1 years (3.6–13.5)) were included. 98/326 (30.6%) patients had a flare within 12 months. Considering US variables separately, only PD-S significantly predicted flare (OR 1.87 (1.12,3.14)). When the model included both –T and –S, only the concurrent presence of –T and –S predicted flare (PD-T+-S: OR 2.06 (1.04, 4.07); GS-T+-S: OR 2.27, (1.01,5.10)), while isolated –S and –T did not.Conclusions In patients with RA in clinical remission, US-detected synovial and tenosynovial inflammation identifies patients at risk of flare. US might help decisions on management in this population.Disclosure of Interest None declared