PT  - JOURNAL ARTICLE
AU  - S. Kleinert
AU  - A. Marx
AU  - H. Faller
AU  - H.-P. Tony
AU  - M. Feuchtenberger
AU  - C. Kneitz
AU  - S. Lehmann
AU  - C. Angermann
AU  - G. Ertl
AU  - S. Störk
AU  - M. Breunig
TI  - FRI0150 Depression, Inflammation and Mortality in Patients with Rheumatoid Arthritis
AID  - 10.1136/annrheumdis-2016-eular.2473
DP  - 2016 Jun 01
TA  - Annals of the Rheumatic Diseases
PG  - 483--483
VI  - 75
IP  - Suppl 2
4099  - http://ard.bmj.com/content/75/Suppl_2/483.1.short
4100  - http://ard.bmj.com/content/75/Suppl_2/483.1.full
SO  - Ann Rheum Dis2016 Jun 01; 75
AB  - Background Patients with rheumatoid arthritis (RA) have a high prevalence of depressive symptoms and an increased mortality.Objectives The current prospective follow-up study investigates prevalence of depression, its association with inflammation and mortality in RA patients.Methods 764 consecutive patients attending the rheumatology outpatient department of the University Hospital Würzburg underwent a comprehensive cardiovascular (CV) risk assessment. Inflammation in RA patients was characterized by DAS28 and CRP. Quality of life and depressive symptoms were investigated by SF-36 and PHQ-9 (range 0–27 score points), respectively. A PHQ score ≥15 points is considered indicative for severe depressive symptoms.Results 352 subjects suffered from rheumatoid arthritis (RA: 79.5% female, 64.9% RF positive, mean age 54.3 (SD 14.3)), Severe or moderate depressive symptoms were prevalent in 6.6%, respectively 14.4% of RA patients. DAS28, but not CRP, was significantly associated with the prevalence of depressive symptoms (r=0.26 (p<0.001), figure A, table 1).View this table:Patients with severe depressive symptoms (PHQ 9 ≥15) had an increased a HR of 6.42 (95% CI, 2.04 – 20.2, p=0.004) for mortality compared to patients with a PHQ ≤14 (figure B).Conclusions DAS28 in RA patients was associated with severity of depressive symptoms. Severely depressed patients had an increased mortality.Disclosure of Interest None declared