TY - JOUR T1 - Influence of diet with different lipid composition on neutrophil chemiluminescence and disease activity in patients with rheumatoid arthritis. JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 793 LP - 796 DO - 10.1136/ard.47.10.793 VL - 47 IS - 10 AU - M Magaro AU - L Altomonte AU - A Zoli AU - L Mirone AU - P De Sole AU - G Di Mario AU - S Lippa AU - A Oradei Y1 - 1988/10/01 UR - http://ard.bmj.com/content/47/10/793.abstract N2 - Neutrophil chemiluminescence was determined in patients with active rheumatoid arthritis. Twelve patients were randomly assigned either to a diet high in polyunsaturated fatty acids supplemented with eicosapentaenoic and docosahexaenoic acids or to a diet high in saturated fatty acids. A correlation with clinical and laboratory parameters is also reported. No statistical difference was observed in neutrophil chemiluminescence and in clinical parameters in the group of patients treated with a diet high in saturated fatty acids. Fish oil ingestion resulted in subjective alleviation of active rheumatoid arthritis and reduction of neutrophil chemiluminescence. This study corroborates the hypothesis of an anti-inflammatory role for polyunsaturated fatty acids in patients with chronic inflammatory diseases. ER -