PT  - JOURNAL ARTICLE
AU  - Femke Intema
AU  - Peter M Van Roermund
AU  - Anne C A Marijnissen
AU  - Sebastian Cotofana
AU  - Felix Eckstein
AU  - Rene M Castelein
AU  - Johannes W J Bijlsma
AU  - Simon C Mastbergen
AU  - Floris P J G Lafeber
TI  - Tissue structure modification in knee osteoarthritis by use of joint distraction: an open 1-year pilot study
AID  - 10.1136/ard.2010.142364
DP  - 2011 May 01
TA  - Annals of the Rheumatic Diseases
PG  - annrheumdis142364
4099  - http://ard.bmj.com/content/early/2011/05/12/ard.2010.142364.short
4100  - http://ard.bmj.com/content/early/2011/05/12/ard.2010.142364.full
AB  - Background Modification of joint tissue damage is challenging in late-stage osteoarthritis (OA). Few options are available for treating end-stage knee OA other than joint replacement. Objectives To examine whether joint distraction can effectively modify knee joint tissue damage and has the potential to delay prosthesis surgery. Methods 20 patients (<60 years) with tibiofemoral OA were treated surgically using joint distraction. Distraction (~5 mm) was applied for 2 months using an external fixation frame. Tissue structure modification at 1 year of follow-up was evaluated radiographically (joint space width (JSW)), by MRI (segmentation of cartilage morphology) and by biochemical markers of collagen type II turnover, with operators blinded to time points. Clinical improvement was evaluated by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analogue Scale (VAS) pain score. Results Radiography demonstrated an increase in mean and minimum JSW (2.7 to 3.6 mm and 1.0 to 1.9 mm; p<0.05 and <0.01). MRI revealed an increase in cartilage thickness (2.4 to 3.0 mm; p<0.001) and a decrease of denuded bone areas (22% to 5%; p<0.001). Collagen type II levels showed a trend towards increased synthesis (+103%; p<0.06) and decreased breakdown (−11%; p<0.08). The WOMAC index increased from 45 to 77 points, and VAS pain decreased from 73 to 31 mm (both p<0.001). Conclusions Joint distraction can induce tissue structure modification in knee OA and could result in clinical benefit. No current treatment is able to induce such changes. Larger, longer and randomised studies on joint distraction are warranted.